Prednisolone plus low-dose aspirin improves the implantation rate in women with autoimmune conditions who are undergoing in vitro fertilization

I Hasegawa, Isao Hasegawa, Y Yamanoto, Yasuaki Yamanoto, M Suzuki, Mina Suzuki, Haruo Murakawa, H Murakawa, Takumi Kurabayashi, T Kurabayashi, K Takakuwa, Koichi Takakuwa, K. Tanaka, Kenichi Tanaka
Fertility and sterility · 1998 · vol. 70(6) , pp. 1044–1048 · doi:10.1016/s0015-0282(98)00343-4 · PMID:9848293 · W2086834246
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Prednisolone combined with low-dose aspirin demonstrated an improved implantation rate in women with autoimmune conditions undergoing in vitro fertilization.

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Abstract

OBJECTIVE: To evaluate the effect of prednisolone plus low-dose aspirin (PSL/LDA) in women with autoimmune conditions who were enrolled in an IVF-ET program. DESIGN: A retrospective clinical study. SETTING: In vitro fertilization unit, Niigata University Hospital, Niigata, Japan. PATIENT(S): Three hundred seven women who underwent IVF-ET between January 1996 and December 1997. INTERVENTION(S): Prednisolone (10 mg/d) and aspirin (81 mg/d) were administered to the women with autoantibodies who chose to participate. MAIN OUTCOME MEASURE(S): Pregnancy and implantation rates with IVF-ET. RESULT(S): Women undergoing IVF who had positive antinuclear antibodies, with or without antiphospholipid antibodies, had significantly lower pregnancy and implantation rates than did women without autoantibodies (14.8% versus 21.7% and 6.8% versus 10.4%, respectively). The administration of PSL/LDA to women with antinuclear antibodies significantly improved the outcome of IVF-ET (40.6% pregnancy rate and 20.3% implantation rate). CONCLUSION(S): A high proportion of women who are undergoing IVF-ET have autoantibodies, which are associated with poor IVF outcomes. The administration of PSL/LDA to these women may improve their implantation rate.

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MeSH descriptors

Aspirin Autoimmune Diseases Embryo Implantation Embryo Transfer Fertilization in Vitro Prednisolone Pregnancy Rate Adult Antibodies, Antinuclear Antibodies, Antinuclear Antibodies, Antiphospholipid Antibodies, Antiphospholipid Aspirin Autoimmune Diseases Dose-Response Relationship, Drug Drug Therapy, Combination Female Humans Prednisolone Pregnancy

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