1H NMR Based Targeted Metabolite Profiling for Understanding the Complex Relationship Connecting Oxidative Stress with Endometriosis

Saikat K Jana, Saikat Kumar Jana, Mainak Dutta, Mamata Joshi, Sudha Srivastava, Baidyanath Chakravarty, Koel Chaudhury
BioMed research international · 2013 · vol. 2013 , pp. 1–9 · doi:10.1155/2013/329058 · PMID:23984345 · W1968923085
article OA: hybrid CC0 ⤵ 51 in-corpus citations
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Proton NMR metabolite profiling revealed elevated glucose metabolism and citrate/succinate in endometriosis patients, correlating with oxidative stress markers and suggesting mitochondrial defects as a source of reactive oxygen species.

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Abstract

Accumulating evidence indicates the active role of oxidative stress in the development of endometriosis; however, the mechanism of reactive oxygen species generation is poorly understood. Metabonomics/metabolomics is a scientific discipline that can be used to study changes in metabolite ensembles associated with disease pathophysiology. The present study focuses on the use of proton nuclear magnetic resonance spectroscopy based targeted metabolite profiling approach to explore dysregulation in metabolites expression in women with endometriosis. Further, association of oxidative stress with the metabolite ensembles, if any, is investigated. Using multivariate statistics, partial least square discriminant analysis model was generated which could classify endometriosis patients with sensitivity and specificity of 92.83% and 100%, respectively, and with a classification rate of 96.4%. In conjunction with increased glucose metabolism, citrate and succinate were found to be elevated in endometriosis patients. Higher levels of reactive oxygen species, lipid peroxidation, and advanced oxidation protein products and lower levels of total antioxidant capacity, superoxide dismutase, catalase, and glutathione were also observed. Increased glucose metabolism and defects in the mitochondrial respiratory system are suggested to be the possible sources of excessive reactive oxygen species generation in endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Magnetic Resonance Spectroscopy Metabolomics Oxidative Stress Protons Adult Case-Control Studies Endometriosis Female Humans Principal Component Analysis Young Adult

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