The effect of metallic copper on human endometrial alkaline phosphatase activity

E. W. Wilson
The Journal of obstetrics and gynaecology of the British Commonwealth · 1973 · vol. 80(7) , pp. 648–650 · doi:10.1111/j.1471-0528.1973.tb16042.x · PMID:4723958 · W2000852698
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Incubating human endometrial homogenates with metallic copper reduced alkaline phosphatase activity specifically during the secretory phase, whereas cupric ions inhibited this enzyme across all menstrual cycle phases.

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Abstract

Summary Homogenates of human endometrium from different stages of the menstrual cycle were incubated with strips of copper foil and with cupric ions. The alkaline photophatase activity in homogenates exposed to metallic copper was reduced only during the secretory phase of the cycle; dissolution of the metallic copper was greater in the secretory phase than in the proliferative phase. Cupric ions inhibited alkaline phosphatase activity at all phases of the cycle.

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MeSH descriptors

Alkaline Phosphatase Copper Endometrium Alkaline Phosphatase Alkaline Phosphatase Cell Division Copper Endometrium Endometrium Endometrium Female Humans In Vitro Techniques Menstruation Time Factors

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