Correlation between overexpression of transforming growth factor-beta 1 in occluded fallopian tubes and postsurgical pregnancy among infertile women

Zhengyu Li, Ying Sun, Wenjiao Min, Dan Zhang
International Journal of Gynecology & Obstetrics · 2010 · vol. 112(1) , pp. 11–14 · doi:10.1016/j.ijgo.2010.07.016 · PMID:20837351 · W2081144937
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Transforming growth factor-beta 1 and its receptors were significantly elevated in occluded fallopian tubes and negatively correlated with postsurgical pregnancy success in infertile women.

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Abstract

OBJECTIVE: To compare the expression profiles of transforming growth factor-beta 1 (TGF-β1) and its receptors in occluded tubes of infertile women with those of control patients and to evaluate the potential correlation with postsurgical pregnancy outcome. METHODS: The expression profiles of TGF-β1, TGF-β1R1, and TGF-β1R2 in occluded fallopian tubes were compared using immunohistochemistry between 60 infertile patients with adhered tubes and 60 control patients with normal tubes; potential correlations with postsurgical fertility were evaluated at 2-year follow up. RESULTS: Immunostainings of TGF-β1, TGF-β1R1, and TGF-β1R2 were all significantly elevated in patients with adhered tubes compared with normal specimens (P<0.001). In adhered specimens, correlation analyses showed positive correlations between TGF-β1 and TGF-β1R1 (P=0.008), and TGF-β1 and TGF-β1R2 (P=0.035). At 2-year follow up, 32 of the 60 infertile women had achieved normal pregnancies, 5 had had ectopic pregnancies, and 23 remained infertile. Correlation analysis showed that TGF-β1 expression level was negatively correlated with pregnancy outcome (r=-0.445, P<0.001), independent of adhesion severity or patient age. CONCLUSION: TGF-β1 expression was independently correlated with the postsurgical pregnancy outcome among infertile women.

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MeSH descriptors

Fallopian Tube Diseases Gene Expression Pregnancy Outcome Transforming Growth Factor beta1 Adult Age Factors Case-Control Studies Fallopian Tube Diseases Fallopian Tube Diseases Fallopian Tube Diseases Female Follow-Up Studies Humans Infertility, Female Infertility, Female Pregnancy Pregnancy Outcome Protein Serine-Threonine Kinases Protein Serine-Threonine Kinases Receptors, Transforming Growth Factor beta

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