Massive breast enlargement in a patient receiving D-penicillamine for systemic sclerosis

Kahl Le, L E Kahl, Medsger TA, T A Medsger, I Klein, Irwin Klein
The Journal of rheumatology · 1985 · vol. 12(5) , pp. 990–1 · PMID:4087275 · W187011460
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D-penicillamine therapy for systemic sclerosis was associated with massive breast enlargement and hyperprolactinemia, which resolved following treatment with danazol.

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Abstract

Breast enlargement is an unusual complication of D-penicillamine therapy for rheumatoid arthritis. We observed breast enlargement and hyperprolactinemia in a woman receiving D-penicillamine for systemic sclerosis. Treatment with danazol was associated with a reduction in both the breast size and the prolactin level.

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MeSH descriptors

Breast Penicillamine Scleroderma, Systemic Aged Breast Danazol Danazol Female Humans Hyperprolactinemia Hyperprolactinemia Hyperprolactinemia Penicillamine Scleroderma, Systemic

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