The study of relationship between the expression of VEGF and Ang-2 and Tie-2 in endometriosis

Dandan Huang
In: Discussion of Clinical Cases · 2016 · vol. 3(2) , pp. 7 · doi:10.14725/dcc.v3n2p7 · W4245789935
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VEGF, Ang-2, and Tie-2 expression increased in endometriosis tissues, correlating with each other and potentially contributing to disease survival and invasion.

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This paper examined expression of vascular endothelial growth factor (VEGF), angiopoietin-2 (Ang-2), and the receptor Tie-2 in 30 specimens across three tissue types: normal endometrium, eutopic endometrium, and ectopic endometrial tissue from endometriosis, using immunohistochemistry and assessing links to menstrual cycle and clinical stage. VEGF positivity increased across groups (16.67%, 86.67%, 90.00%), Ang-2 positivity differed by tissue type (33.33%, 70.00%, 60.00%), and Tie-2 positivity increased similarly (13.33%, 50.00%, 40.00%), with reported statistical significance. VEGF, Ang-2, and Tie-2 expression levels were strongly correlated with each other (correlation coefficients ~0.875–0.905). A key limitation is that the abstract and provided content do not report specific menstrual-cycle or clinical-stage stratified results, nor do they describe sample-size/power details beyond the total 30 specimens. This paper is centrally about endometriosis — it measures VEGF, Ang-2, and Tie-2 expression in endometriosis-related ectopic versus eutopic and normal endometrial tissues.

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Abstract

Objective: To detect the expression of VEGF (vascular endothelial growth factor), Ang-2 (angiopoietin-2) and Tie-2 in endometriosis (EMs) and their correlations with menstrual cycle and clinical stage. Methods: Thirty specimens of normal endometrium, eutopic endometrium and ectopic endometrium tissues were collected. The expression of VEGF, Ang-2 and Tie-2 was detected by immunohistochemistry methods. Results: The positive rate of expression of VEGF in the normal endometrium, eutopic endometrium and ectopic endometrium tissues gradually increased (16.67%, 86.67%, 90.00%), compared three groups ( p < .01). The positive rate of expression of Ang-2 in the normal endometrium, eutopic endometrium and ectopic endometrium tissues was 33.33%, 70.00%, 60.00%, respectively ( p < .05). The positive rate of expression of Tie-2 in the normal endometrial, eutopic endometrium and ectopic endometrial tissues was 13.33%, 50.00%, 40.00%, respectively ( p < .01). The expression of VEGF, Ang-2 and Tie-2 was closely correlated with each other (r = 0.875, r = 0.905, r = 0.898). Conclusions: Our findings suggest that there is a close relation between VEGF, Ang-2 and Tie-2, the up-regulation of VEGF and Ang-2 may cooperatively contribute to survival and invasion of EMs. This may provide new targets for therapy of EMs.
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Abstract

Objective: To detect the expression of VEGF (vascular endothelial growth factor), Ang-2 (angiopoietin-2) and Tie-2 in endometriosis (EMs) and their correlations with menstrual cycle and clinical stage.

Methods

Thirty specimens of normal endometrium, eutopic endometrium and ectopic endometrium tissues were collected. The expression of VEGF, Ang-2 and Tie-2 was detected by immunohistochemistry methods.

Results

The positive rate of expression of VEGF in the normal endometrium, eutopic endometrium and ectopic endometrium tissues gradually increased (16.67%, 86.67%, 90.00%), compared three groups (p < .01). The positive rate of expression of Ang-2 in the normal endometrium, eutopic endometrium and ectopic endometrium tissues was 33.33%, 70.00%, 60.00%, respectively (p < .05). The positive rate of expression of Tie-2 in the normal endometrial, eutopic endometrium and ectopic endometrial tissues was 13.33%, 50.00%, 40.00%, respectively (p < .01). The expression of VEGF, Ang-2 and Tie-2 was closely correlated with each other (r = 0.875, r = 0.905, r = 0.898).

Conclusions

Our findings suggest that there is a close relation between VEGF, Ang-2 and Tie-2, the up-regulation of VEGF and Ang-2 may cooperatively contribute to survival and invasion of EMs. This may provide new targets for therapy of EMs. Full Text: PDFDOI: https://doi.org/10.5430/dcc.v3n2p7 Refbacks - There are currently no refbacks.

Discussion

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Condition tags

endometriosis

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