The role of danazol in the management of precocious puberty

C S Smith, Smith Cs, F Harris, Francesca Harris
Postgraduate medical journal · 1979 · vol. 55 Suppl 5 , pp. 81–6 · PMID:537954 · W2410630475
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Danazol was evaluated in 12 children with precocious puberty and found to effectively control secondary sexual features without altering linear growth or skeletal maturation.

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Abstract

The management, investigation and treatment of 12 children with precocious puberty is described. Danazol, a synthetic derivative of ethisterone, has been used over a period of 3 1/2 years. Its clinical, endocrine and biochemical effects have been evaluated. Danazol ha a very useful clinical effect in controlling the development of secondary sexual features but does not modify the rapid linear growth and skeletal maturity seen in this condition.

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MeSH descriptors

Danazol Pregnadienes Puberty, Precocious 17-Ketosteroids 17-Ketosteroids Body Height Body Height Child Child, Preschool Danazol Electroencephalography Female Follicle Stimulating Hormone Follicle Stimulating Hormone Humans Infant Luteinizing Hormone Luteinizing Hormone Male Pregnadienes

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