Effects of danazol and lynestrenol on serum lipoproteins in endometriosis

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Treatment of endometriosis with danazol and lynestrenol decreased HDL cholesterol and increased LDL cholesterol, with lynestrenol's effects attributed to progestational activity and danazol's to antigonadotropic and androgenic activities.

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Abstract

The treatment of endometriosis with danazol or lynestrenol decreased cholesterol content of plasma high-density lipoproteins by 50% and 32%. There were simultaneous increases in low-density lipoprotein cholesterol content of 51% and 19%. We suggest that changes induced by lynestrenol are due to progestational activity, while in the case of danazol both antigonadotropic and androgenic activities are involved.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Lipoproteins Lynestrenol Pregnadienes Adult Adult Danazol Danazol Endometriosis Endometriosis Endometriosis Female Female Humans Humans Lipoproteins Lipoproteins Lynestrenol Lynestrenol

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (12)

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europepmc
last seen: 2026-10-16T06:09:50.462052+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:58:49.153990+00:00
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License: CC0 · commercial use OK