Low Serum Vitamin D and Normal Serum 8-Hydroxy-2-Deoxyguanosine Levels in Endometrioma Patients: Is It a Dilemma?

Neslihan Bayramoğlu Tepe, Özcan Balat, Tanyeli Güneyligil Kazaz, Hüseyin Çağlayan Özcan, Seyhun Sucu, Özge Kömürcü Karuserci, Mete Gürol Uğur, Hilmi TAŞDEMİR
2019 · W3001817832
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This study compared serum vitamin D and 8-OH2dG levels in endometrioma patients versus controls, finding significantly lower vitamin D but unchanged oxidative stress markers among the patients.

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This study investigated the relationship between serum vitamin D levels and oxidative stress markers in patients with endometriomas. The researchers measured 8-hydroxy-2-deoxyguanosine as a marker of oxidative damage alongside vitamin D concentrations in women diagnosed with this condition. They found that while patients had significantly low serum vitamin D levels, their 8-hydroxy-2-deoxyguanosine levels remained within normal ranges. This apparent contradiction presents a dilemma regarding the role of oxidative stress in endometrioma pathogenesis when vitamin D deficiency is present. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

Amac: Endometrioma hastalarinda serum 25-OH vitamin D ve 8-Hidroksi 2-deoksigunazin (8-OH2dG) seviyelerini karsilastirmak, kist boyutu ile iliskisini saptamak. Gerec ve Yontemler: Calismaya endometrioma tanisi alan 54 hasta ile normal over dokusuna sahip 26 hasta kontrol grubu olarak dahil edildi. Serum orneklerinde 25-OH vitamin D ve 8-OH2dG seviyelerine bakildi. Bulgular: Hasta ve kontrol grubu arasinda yas, gebelik, dogum sayisi ve vucut kitle indexi (VKI) bakimindan farklilik yoktu. Hasta grubunun D vitamini duzeyi, kontrol grubuna gore anlamli derecede dusuktu (p=0.001). Kisti bilateral olan hastalar ile, kisti unilateral olan hastalar arasinda D vitamini duzeyleri bakimindan anlamli farklilik yoktu (p=0.39). Hasta grubunda 48 (%88.8), kontrol grubunda 11 (%42.3) hastada D vitamini seviyesi 0.05). Sonuc: Endometrioma varligi, kist capi ve serum D vitamini duzeyleri arasinda ters iliski olmasina ragmen, serum 8-OH2dG duzeylerinde degisiklik yoktu. Bu durum, overyan endometriozisin patogenezinde hala belirsiz noktalar oldugunu gostermektedir.
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Low Serum Vitamin D and Normal Serum 8-Hydroxy-2-Deoxyguanosine Levels in Endometrioma Patients: Is It a Dilemma? Öz Anahtar Kelimeler Kaynakça - Referans 1. Guidice LC, Tazuke SI, Swiersz L. Status of current research on endometriosis. J Reprod Med 1998; 43(3): 252-262. - Referans 2 . Sourial S, Tempest N, Hapangama DK. Theroies on the pathogenesis of endometriosis. Int J Reprod Med 2014:179515. - Referans 3. Missmer SA, Cramer DW. The epidemiology of endometriosis. Obstet Gynecol Clin N Am 2003; 30:1-19 - Referans 4. Buggio L, Roncella E, Somigliana E, Vercellini P. Vitamin D and benign gynaecological diseases: a critical analysis of the current evidence. Gynecol Endocrinol 2016; 32 (4): 259-263. - Referans 5. Vigano P, Lattuada D, Mangioni S, et al. Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. J. Mol. Endocrinol 2006; 36: 415-424. - Referans 6. Christodoulakos G, Augoulea A, Lambrinoudaki I, Sioulas V, Creatsas G. Pathogenesis of endometriosis: the role of defective ‘immunosurveillance’. The European Journal of Contraception & Reproductive Health Care 2007; 12(3): 194–202. - referans 7. Augoulea A, Mastorakos G, Lambrinoudaki I, Christodoulakos G, Creatsas G. The role of the oxidative stress in the endometriosis-related infertility. Gynecological Endocrinology 2009; 25(2): 75–81. - Referans 8. Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reproductive Biology and Endocrinology 2005; 3: 28. Ayrıntılar Birincil Dil İngilizce Konular Kadın Hastalıkları ve Doğum Bölüm Araştırma Makalesi Yazarlar Özcan Balat 0000-0002-9158-0009 Türkiye Hüseyin Ozcan 0000-0002-4922-7148 Türkiye Seyhun Sucu 0000-0001-6821-4070 Türkiye Mete Gürol Uğur 0000-0002-0720-970X Türkiye Hilmi Taşdemir 0000-0002-7820-6290 Türkiye Yayımlanma Tarihi 31 Aralık 2019 Gönderilme Tarihi 27 Aralık 2019 Kabul Tarihi 29 Aralık 2019 Yayımlandığı Sayı Yıl 2019 Cilt: 16 Sayı: 4

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