Dysregulated cell mechanical properties of endometrial stromal cells from endometriosis patients.

Zhiyong Wu, Zhi-Yong Wu, Xiao-Mei Yang, Xiaomei Yang, Mingjun Cheng, Ming-Jun Cheng, Rong Zhang, Jun Ye, Huan Yi, Jun-Ping Ao, Junping Ao, Zhi-Gang Zhang, Zhigang Zhang, Congjian Xu, Cong-Jian Xu
International journal of clinical and experimental pathology · 2014 · vol. 7(2) , pp. 648–55 · PMID:24551285 · W341581136
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Abstract

Endometriosis, diagnosed with ectopically implanted endometrial stromal cells (ESC) and epithelial cells to a location outside the uterine cavity, seriously threaten the quality of life and reproductive ability of women, yet the mechanisms and the pathophysiology of the disease remain unclear. Specially, the functional changes of ESC during endometriosis progression need in-depth investigation. In this study, we characterized mechanical properties of normal ESC (NESC) from healthy women and eutopic ESC (EuESC) and ectopic ESC (EcESC) from endometriosis patients. We found the collagen lattice contractile ability of EuESC was significantly stronger than that of NESC, and the cell mobility of EuESC and EcESC was significantly greater than that of NESC. Furthermore, the expression of F-actin and vinculin in NESC, EuESC and EcESC cells progressively increased, and the Rho GTPase activity, of which RhoA exhibited the highest activity, in the three cells gradually increased. Collectively, these results suggest that the mechanical characteristics of NESC, EuESC and EcESC cells exhibited progressive abnormalities. Therefore, the biomechanics of endometrial stromal cells may be a potent target for intervention in patients with endometriosis.

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mesh:D004715endometriosis

MeSH descriptors

Cell Movement Endometriosis Endometrium Stromal Cells Actins Actins Biomechanical Phenomena Case-Control Studies Cells, Cultured Collagen Collagen Endometriosis Endometriosis Endometrium Endometrium Female Humans rhoA GTP-Binding Protein rhoA GTP-Binding Protein Stromal Cells

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