Intraventricular administration of l-kynurenine and kynuramine facilitates lordosis in the female rat

Scott D. Mendelson, S D Mendelson, Nancy Lee, N Lee, B B Gorzalka, Boris B. Gorzalka
European journal of pharmacology · 1987 · vol. 142(3) , pp. 447–451 · doi:10.1016/0014-2999(87)90086-0 · PMID:3428356 · W1968191568
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Intraventricular administration of l-kynurenine and kynuramine facilitated lordosis behavior in estrogen-primed ovariectomized rats, indicating these tryptophan metabolites modulate female sexual behavior independently of progesterone pathways.

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Abstract

Intraventricular administration of the tryptophan metabolites l-kynurenine (2-32 micrograms) and kynuramine (0.064-8 micrograms) facilitated lordosis behavior in estrogen-primed ovariectomized rats. The facilitatory effects of these drugs were not attenuated by pretreatment with the progesterone antagonist RU 38486, indicating that the effects were not mediated by release of adrenal progesterone. It is suggested that l-kynurenine and kynuramine may serve a physiological role in the modulation of female sexual behavior.

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MeSH descriptors

Kynuramine Kynurenine Propiophenones Sexual Behavior, Animal Animals Estradiol Estradiol Estrenes Estrenes Female Glucocorticoids Glucocorticoids Injections, Intraventricular Kynuramine Kynuramine Kynurenine Kynurenine Mifepristone Propiophenones Rats

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References (11)

SciLite annotations

chemicals 10
l-kynurenine kynuramine tryptophan l-kynurenine kynuramine estrogen progesterone ru 5135 progesterone l-kynurenine
organisms 2
zitter rats rattus sp.

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