Endothelial microparticles in transplant patients - great potential but a long way to go

Horace Roman; Sergey V Brodsky; Anjali Satoskar; Tibor Nadasdy

doi:10.2741/426

Endothelial microparticles in transplant patients - great potential but a long way to go

Horace Roman, Sergey V Brodsky, Anjali Satoskar, Tibor Nadasdy

Frontiers in bioscience (Elite edition) · 2011 · vol. 7(1) , pp. 83–93 · doi:10.2741/426 · PMID:22201921 · W2330173907

Review OA: closed CC0 ⤵ 2 in-corpus citations

Full text JSON View on OpenAlex View on PubMed View at publisher

⚙ AI-generated summary by qwen3.7-flash, 2026-09-10 ⓘ

This paper reviews conflicting evidence on primary surgery versus IVF for colorectal endometriosis in women desiring pregnancy, highlighting risks of delayed intervention and the need for large randomized trials.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-10 · read from full text ⓘ

This review article examines the clinical management debate regarding patients with deep infiltrating colorectal endometriosis who desire pregnancy, noting the absence of high-level evidence to guide treatment decisions. It contrasts primary in vitro fertilization, which yields cumulative pregnancy rates up to 68%, against primary surgical excision, where spontaneous conception accounts for a significant portion of successful outcomes despite comparable overall rates. The authors highlight that delaying surgery may impair health by increasing risks of bowel occlusion, more radical procedures, and prolonged pain, suggesting these factors are critical considerations alongside fertility success. This paper is centrally about endometriosis — specifically the decision-making process between surgical excision and assisted reproductive technologies for deep infiltrating colorectal lesions.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

This overview provides information on the current state of endothelial microparticle research. Microparticles are small membrane vesicles shed by different cell types, which contain cell surface proteins and cytoplasmic components of the original cell. The microparticle production is a part of normal cell function, but it increases by apoptotic cells and cells under stress. Numerous evidences suggest that circulating endothelial microparticles may be a marker of endothelial cell function. Endothelial cells play an important role in the pathogenesis of allograft dysfunction and rejection. The endothelium is one of the main targets in allograft rejection. Recent studies have indicated that levels of circulating endothelial microparticles change in patients with solid organ transplants, including kidneys. We believe that circulating endothelial microparticles may be a useful tool of allograft function monitoring and/or a diagnostic marker of allograft rejection.

Full text 1,923 characters · extracted from oa-doi-fallback · 2 sections · click to expand

Abstract

One of the most interesting debates surrounding deep endometriosis concerns the management of patients with colorectal lesions and pregnancy intention, for which no strong first level of evidence data exists to recommend performing surgical excision of colorectal endometriosis or ART. Studies assessing the policy of primary IVF have recorded pregnancy rates inferior to 45% and estimated cumulative pregnancy rates after up to 3 cycles or IVF as high as 68%. Other authors have reported pregnancy rates over 60% in patients undergoing primary surgery for colorectal endometriosis, with spontaneous conception representing up to 60% of pregnancies. Although overall pregnancy rates appear roughly comparable in patients undergoing either IVF followed by surgery or surgery followed if required by IVF, questions remain as to whether delaying surgery for months or years impairs health. Delaying surgery may lead to bowel occlusion, higher rates of radical colorectal procedures, increased postoperative morbidity and prolonged painful complaints. To provide definitive answers requires a randomized trial on an international scale with a sample size exceeding 400 patients and follow up averaging 4 years.

Keywords

- Deep Endometriosis - Colorectal Endometriosis - Fertility - Infertility - IVF - Surgery - Complications - Review

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

MeSH descriptors

Endothelium Transplantation Endothelium Humans

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cited by (2)

Source provenance

openalex: last seen: 2026-06-04T00:00:01.174412+00:00
pubmed: last seen: 2026-10-08T21:09:44.076416+00:00
unpaywall: last seen: 2026-10-21T06:41:41.500114+00:00

License: CC0 · commercial use OK