Association of polymorphisms of the MMP-2 and TIMP-2 genes with the risk of endometriosis in North Chinese women

Shan Kang, Kang S, Xi-Wa Zhao, Zhao XW, Xiwa Zhao, Na Wang, Wang N, Chen SC, Shu-Cheng Chen, Shu‐Cheng Chen, Rong‐Miao Zhou, Rong-miao Zhou, Zhou RM, Yan Li, Li Y
Fertility and sterility · 2008 · vol. 90(5) , pp. 2023–2029 · doi:10.1016/j.fertnstert.2007.09.068 · PMID:18177649 · W2007923745
Observational OA: bronze CC0 ⤵ 16 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-09 ⓘ

This study examined MMP-2 and TIMP-2 gene polymorphisms and found the TIMP-2 -418C/C homozygote may protect against endometriosis in North Chinese women.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

We investigated whether three polymorphisms in the matrix metalloproteinase-2 (MMP-2; -1306C-->T and -735C-->T) and tissue inhibitor of metalloproteinase-2 (TIMP-2; -418G-->C) genes were related to the risk of endometriosis in reproductive-aged women with and without endometriosis. Our results indicate that the TIMP-2 -418C/C homozygote may be a protective factor against the development of endometriosis in North Chinese women.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Asian People Endometriosis Matrix Metalloproteinase 2 Polymorphism, Single Nucleotide Polymorphism, Single Nucleotide Tissue Inhibitor of Metalloproteinase-2 Adult Adult Asian People Asian People Case-Control Studies Case-Control Studies China China China Endometriosis Endometriosis Endometriosis Endometriosis Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (36)

Cited by (16)

Source provenance

europepmc
last seen: 2026-10-18T09:30:06.152893+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:05:01.267406+00:00
License: CC0 · commercial use OK