Combined (hormonal and microsurgical) therapy in infertile women with endometriosis

Donnez J, J. Donnez, Lemaire-Rubbers M, M Lemaire-Rubbers, Y Karaman, Karaman Y, M Nisolle-Pochet, Nisolle-Pochet M, F. Casanas-roux, Casanas-Roux F
Fertility and sterility · 1987 · vol. 48(2) , pp. 239–42 · doi:10.1016/s0015-0282(16)59349-2 · PMID:3609335
Non-randomised trial OA: closed public-domain-us
🔓 Open OA copy View on PubMed View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-10-01 ⓘ

In 50 women with moderate or severe endometriosis, six months of lynestrenol followed by microsurgery yielded pregnancy rates of 60% and 47%, respectively.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Fifty patients with moderate or severe endometriosis received 5 mg/day lynestrenol for 6 months prior to microsurgery. A significant regression of the ovarian and peritoneal implants was observed in 72% of the cases after progestative treatment, but the presence of residual epithelium in all cases made surgical resection necessary. After preoperative medical treatment and microsurgery, intrauterine (living births) pregnancy rates of 60 and 47% were obtained in cases of moderate and severe endometriosis, respectively. The following prognostic factors were found in this series: the degree of endometriosis, the concomitant male factors, the decrease of endometriotic lesions after treatment, and the unilaterality of ovarian endometriosis.

My notes (saved in your browser only)

Condition tags

dyspareuniaendometriosis

MeSH descriptors

Endometriosis Infertility, Female Adult Adult Body Weight Body Weight Body Weight Combined Modality Therapy Combined Modality Therapy Dyspareunia Dyspareunia Dyspareunia Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans Humans

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

europepmc
last seen: 2026-11-04T06:09:08.831786+00:00
pubmed
last seen: 2026-10-08T21:36:45.364535+00:00
unpaywall
last seen: 2026-09-17T06:32:46.214484+00:00
License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine