The value of DWI and IVIM for predicting the outcome of adenomyosis-associated infertile patients before transferring frozen-thawed embryos

Yuan Jiang, Xin Li, Jianxiu Lian, Li Wei, Naishan Qin
In: ISMRM Annual Meeting · 2025 · doi:10.58530/2025/3029 · W4414233248
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This study found that ADC values derived from IVIM-DWI imaging before frozen-thawed embryo transfer showed potential for predicting pregnancy outcomes in adenomyosis-associated infertile patients.

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The study evaluated whether intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) parameters measured before frozen-thawed embryo transfer could predict pregnancy outcomes in 19 adenomyosis-associated infertile patients who received GnRH-a pretreatment. Using IVIM-DWI, the authors calculated ADC-related metrics for adenomyosis, including ADC, D, D*, and f, and compared these between pregnancy and non-pregnancy groups. They found that ADC was significantly higher in the pregnancy group than the non-pregnancy group (p = 0.021), while other diffusion-related parameters did not show significant differences. The study is limited by its small sample size and provides only preliminary evidence needing further study. This paper is centrally about adenomyosis — it tests whether IVIM/DWI imaging before frozen-thawed embryo transfer can predict pregnancy outcomes in adenomyosis-associated infertile patients after GnRH-a pretreatment.

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Abstract

Motivation: The of embryo frozen-thawed transfer with GnRH-a pretreatment of adenomyosis-associated infertile patients are still controversial, despite its significance in clinical practice. Goal(s): To assess the predictive capability of intravoxel incoherent motion diffusion‐weighted (IVIM) imaging before transferring embryos in identifying adenomyosis-associated infertile patients' outcome. Approach: IVIM-DWI of 19 adenomyosis-associated infertile patients who underwent GnRH-a pretreatment and frozen-thawed embryo transfers were obtained.ADC, D，D* and f of adenomyosis could be calculated. Results: ADC in pregnancy group is significantly higher than that in non-pregnancy group (p =0.021)，but remain no significant difference. Impact: The DWI of adenomyosis before transferring embryos may have the potential capability to predict the pregnancy outcome of adenomyosis-associated infertile patients pretreated by GnRH-a before transferring frozen-thawed embryos, which need further study.
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Abstract

#3029 Yuan Jiang1, Xin Li1, Jianxiu Lian2, Wei Li1, and Naishan Qin1 1Peking University First Hospital, Beijing, China, 2Philips Healthcare, Beijing, China

Keywords

Uterus, IVIM Motivation: The of embryo frozen-thawed transfer with GnRH-a pretreatment of adenomyosis-associated infertile patients are still controversial, despite its significance in clinical practice. Goal(s): To assess the predictive capability of intravoxel incoherent motion diffusion‐weighted (IVIM) imaging before transferring embryos in identifying adenomyosis-associated infertile patients’ outcome. Approach: IVIM-DWI of 19 adenomyosis-associated infertile patients who underwent GnRH-a pretreatment and frozen-thawed embryo transfers were obtained.ADC, D，D* and f of adenomyosis could be calculated.

Results

ADC in pregnancy group is significantly higher than that in non-pregnancy group (p =0.021)，but remain no significant difference. Impact: The DWI of adenomyosis before transferring embryos may have the potential capability to predict the pregnancy outcome of adenomyosis-associated infertile patients pretreated by GnRH-a before transferring frozen-thawed embryos, which need further study. How to access this content: For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library. After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library. After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers. Keywords

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