Mast cells accumulate in rat bone marrow after ovariectomy

Philippe Lesclous, P Lesclous, J L Saffar, Saffar Jl
Cells, tissues, organs · 1999 · vol. 164(1) , pp. 23–29 · doi:10.1159/000016639 · PMID:10940670 · W2015800977
Lab / animal OA: closed CC0 ⤵ 1 in-corpus citation
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

Ovariectomy in rats significantly increases bone marrow mast cell numbers, particularly of the mucosal subtype, alongside increased osteoclast activity and osteopenia.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

We have previously shown that mast cells (MC) may act as accessory cells of bone resorption in a synchronized model of resorption. The aim of this study was to verify whether bone marrow MC accumulated during the phase of rapid osteopenia development in estrogen-deprived rats. Sprague-Dawley rats, 90 days old, were subjected to bilateral ovariectomy (OVX) or sham surgery (controls). Bone histomorphometry was performed in the proximal tibia metaphysis. Thirty days after surgery, serum estradiol had dropped (p < 0.002), and osteopenia was well established in the OVX rats (trabecular bone volume decreased by 69%, p < 0.0001). The indices of bone resorption were strongly modified: the number (p < 0.0001) and individual activity (p < 0.001) of the trabecular osteoclasts were prominently increased in the OVX rats. Ovariectomy resulted in a dramatic increase in the number of bone marrow MC (p < 0.0001), 97% of which were of the mucosal subtype. These results show that MC accumulate concomitantly with osteoclast generation in estrogen-deficient rats. Although the biological significance of this MC increase is unknown from these results, we hypothesize that MC might play a role in ovariectomy-induced bone loss similar to that they we previously proposed in a mechanically activated model of resorption.

My notes (saved in your browser only)

MeSH descriptors

Bone Marrow Cells Mast Cells Osteoporosis Animals Body Weight Bone Marrow Cells Bone Marrow Cells Cell Count Disease Models, Animal Estradiol Estradiol Female Mast Cells Mast Cells Osteoclasts Osteoclasts Osteoclasts Osteoporosis Ovariectomy Rats

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (1)

Cited by (1)

References (37)

Cited by (1)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T20:59:30.381419+00:00
unpaywall
last seen: 2026-10-26T06:31:53.434635+00:00
License: CC0 · commercial use OK