Inhibition of ovulation and fertilization by indomethacin and effect of prostaglandin-F2 alpha on early pregnancy in the rabbit

I F Lau, S K Saksena
Prostaglandins and medicine · 1979 · vol. 2(6) , pp. 425–431 · doi:10.1016/0161-4630(79)90126-5 · PMID:552093 · W1987492259
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This rabbit study found that indomethacin blocks ovulation and inhibits fertilization, while intravaginal prostaglandin-F2α terminates early pregnancy only when administered on day seven, suggesting resistance of young corpora lutea to the treatment.

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Abstract

Ovulation induced by HCG in rabbits was blocked by a single subcutaneous injection of 6 mg/kg indomethacin given 6 h after the insemination and HCG treatment. In addition, a time-dependent inhibition in the fertilization rate after indomethacin treatment was also recorded. This suggests that indomethacin, when given at a critical time and at an appropriate dose level, not only blocks ovulation but also interferes with fertilization. Treatment with graded amounts of prostaglandin-F2 alpha incorporated in a Silastic-polyvinylpyrrolidone-gel (PVP) had marginal to no effect after intravaginal placement on 4- or 6-day pregnancy. However, 5 mg PGF 2 alpha/ Silastic-PVP tube when placed intravaginally on Day-7 of pregnancy resulted in termination of pregnancy in 66% of the treated does. This implies that young corpora lutea are resistant of PGF2 alpha treatment and that pregnancy at the time of ovo-implantation can be terminated by PGF2 alpha incorporated in a Silastic-PVP tube.

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MeSH descriptors

Fertilization Indomethacin Ovulation Pregnancy, Animal Prostaglandins F, Synthetic Animals Corpus Luteum Corpus Luteum Female Fertilization Gestational Age Indomethacin Ovulation Pregnancy Pregnancy, Animal Prostaglandins F, Synthetic Rabbits

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