Identificazione e dosaggio di marcatori molecolari dell'endometriosi nel sangue periferico

Amira Elmakky
2011 · doi:10.6092/unibo/amsdottorato/3889 · W599075271
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This case-control study evaluated peripheral blood markers in 60 women, finding that a combination of serum CA-125 and CA19-9 with molecular markers like Survivin mRNA improved the diagnostic sensitivity for endometriosis compared to individual markers.

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This case-control study evaluated the diagnostic utility of serum CA-125, CA19-9, and peripheral blood mRNA levels for MMP-3, MMP-9, VEGF, and Survivin in distinguishing women with endometriosis from healthy controls. The research included 60 participants, comprising twenty controls matched with twenty patients each having ovarian or deep infiltrating endometriosis, analyzing marker performance via ROC curves and logistic regression. Results indicated that while no significant differences existed between ovarian and deep disease subtypes, a multivariable model combining these markers achieved an 87% sensitivity at a 10% false positive rate, outperforming individual markers like CA125. This paper is centrally about endometriosis — specifically investigating molecular biomarkers for diagnosis and differentiating between deep infiltrating and ovarian forms.

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Abstract

Purpose: to quantify the mRNA levels of MMP-3, MMP-9, VEGF and Survivin in peripheral blood and the serum levels of CA-125, Ca19-9 in women with and without endometriosis and to investigate the performance of these markers to differentiate between deep and ovarian endometriosis. Methods: a case controls study enrolled a series of 60 patients. Twenty controls have been matched with 20 cases of ovarian and 20 cases of deep endometriosis. Univariable and multivariable performance of serum CA125 and CA19-9, mRNA for Survivin, MMP9, MMP3 and VEGF genes have been evaluated by means of ROC curves and logistic regression respectively. Results: No difference in markers concentration were detected between ovarian and deep endometriosis. In comparison with controls serum CA19 and CA125 yielded the better sensitivity followed by mRNA for Survivin gene (81.5%, 51.9% and 7.5% at 10% false positive rate respectively). Multivariable estimated odds of endometriosis yielded a sensitivity of 87% at the same false positive rate. Conclusions: A combination of serum and molecular markers could allow a better diagnosis of endometriosis.
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Abstract

Purpose: to quantify the mRNA levels of MMP-3, MMP-9, VEGF and Survivin in peripheral blood and the serum levels of CA-125, Ca19-9 in women with and without endometriosis and to investigate the performance of these markers to differentiate between deep and ovarian endometriosis.

Methods

a case controls study enrolled a series of 60 patients. Twenty controls have been matched with 20 cases of ovarian and 20 cases of deep endometriosis. Univariable and multivariable performance of serum CA125 and CA19-9, mRNA for Survivin, MMP9, MMP3 and VEGF genes have been evaluated by means of ROC curves and logistic regression respectively.

Results

No difference in markers concentration were detected between ovarian and deep endometriosis. In comparison with controls serum CA19 and CA125 yielded the better sensitivity followed by mRNA for Survivin gene (81.5%, 51.9% and 7.5% at 10% false positive rate respectively). Multivariable estimated odds of endometriosis yielded a sensitivity of 87% at the same false positive rate.

Conclusions

A combination of serum and molecular markers could allow a better diagnosis of endometriosis.

Abstract

Purpose: to quantify the mRNA levels of MMP-3, MMP-9, VEGF and Survivin in peripheral blood and the serum levels of CA-125, Ca19-9 in women with and without endometriosis and to investigate the performance of these markers to differentiate between deep and ovarian endometriosis.

Methods

a case controls study enrolled a series of 60 patients. Twenty controls have been matched with 20 cases of ovarian and 20 cases of deep endometriosis. Univariable and multivariable performance of serum CA125 and CA19-9, mRNA for Survivin, MMP9, MMP3 and VEGF genes have been evaluated by means of ROC curves and logistic regression respectively.

Results

No difference in markers concentration were detected between ovarian and deep endometriosis. In comparison with controls serum CA19 and CA125 yielded the better sensitivity followed by mRNA for Survivin gene (81.5%, 51.9% and 7.5% at 10% false positive rate respectively). Multivariable estimated odds of endometriosis yielded a sensitivity of 87% at the same false positive rate.

Conclusions

A combination of serum and molecular markers could allow a better diagnosis of endometriosis. Tipologia del documento Tesi di dottorato Autore Elmakky, Amira Supervisore Co-supervisore Dottorato di ricerca Scuola di dottorato Scienze biologiche, biomediche e biotecnologiche Ciclo 23 Coordinatore Settore disciplinare Settore concorsuale Parole chiave Endometriosis VEGF MMPs Survivin URN:NBN Data di discussione 14 Aprile 2011 URI Altri metadati Tipologia del documento Tesi di dottorato Autore Elmakky, Amira Supervisore Co-supervisore Dottorato di ricerca Scuola di dottorato Scienze biologiche, biomediche e biotecnologiche Ciclo 23 Coordinatore Settore disciplinare Settore concorsuale Parole chiave Endometriosis VEGF MMPs Survivin URN:NBN Data di discussione 14 Aprile 2011 URI Gestione del documento:

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endometriosis

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