Uterine receptivity to human embryonic implantation: histology, biomarkers, and transcriptomics

L Aghajanova, Lusine Aghajanova, A E Hamilton, Hamilton AE, Giudice LC, L C Giudice
Seminars in cell & developmental biology · 2008 · vol. 19(2) , pp. 204–11 · doi:10.1016/j.semcdb.2007.10.008 · PMID:18035563 · PMC2829661
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This review examines histology, clinical approaches, and transcriptomics to elucidate mechanisms of uterine receptivity for diagnosing and treating implantation-based disorders such as miscarriage, fetal growth restriction, pre-eclampsia, and infertility.

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Abstract

Embryonic implantation is a dynamic process of paracrine interactions between the maternal compartment and the conceptus and involves a receptive endometrium and a developmentally competent blastocyst. Herein, we review histology, clinical approaches, and the promise of transcriptomics in elucidating mechanisms underlying implantation and development of biomarkers of uterine receptivity-with an eye to diagnose and treat implantation-based disorders of miscarriage, fetal growth restriction, pre-eclampsia, and infertility.

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MeSH descriptors

Embryo Implantation Embryo Implantation Gene Expression Profiling Uterus Uterus Biomarkers Biomarkers Biomarkers Cells, Cultured Embryo Implantation Endometrium Endometrium Female Humans Menstrual Cycle Menstrual Cycle Models, Biological Pregnancy Uterus Uterus

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