Primary signet ring cell carcinoma of the appendix: a rare case report and our 18-year experience

Yoon-Ho Ko, Chan-Kwon Jung, Chan Kwon Jung, Soon-Nam Oh, Soon Nam Oh, Tae-Hee Kim, Tae Hee Kim, Hye-Sung Won, Hye Sung Won, Jin-Hyoung Kang, Jin Hyoung Kang, Hyung-Jin Kim, Hyung Jin Kim, Won Kyung Kang, Won-Kyung Kang, Seong-Taek Oh, Seong Taek Oh, Young Seon Hong, Young-Seon Hong
World journal of gastroenterology · 2008 · vol. 14(37) , pp. 5763 · doi:10.3748/wjg.14.5763 · PMID:18837098 · PMC2748216 · W2101763081
Case report OA: hybrid CC0 ⤵ 2 in-corpus citations
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This report describes a 67-year-old woman with primary signet ring cell carcinoma of the appendix who underwent surgery and chemotherapy, remaining disease-free for twelve months.

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Abstract

Primary adenocarcinoma of the appendix is a rare malignancy that constitutes < 0.5% of all gastrointestinal neoplasms. Moreover, primary signet ring cell carcinoma of the appendix is an exceedingly rare entity. We have encountered 15 cases of primary appendiceal cancer among 3389 patients who underwent appendectomy over the past 18 years. In the present report, we describe a rare case of primary signet ring cell carcinoma of the appendix with ovarian metastases and unresectable peritoneal dissemination occurring in a 67-year-old female patient. She underwent appendectomy and bilateral salpingo-oophorectomy with a laparoscopy procedure. She then received palliative systemic chemotherapy with 12 cycles of oxaliplatin, 5-flurorouracil, and leucovorin (FOLFOX-4). The patient currently is well without progression of disease 12 mo after beginning chemotherapy.

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MeSH descriptors

Appendiceal Neoplasms Carcinoma, Signet Ring Cell Ovarian Neoplasms Peritoneal Neoplasms Adult Aged Antineoplastic Combined Chemotherapy Protocols Antineoplastic Combined Chemotherapy Protocols Appendectomy Appendiceal Neoplasms Appendiceal Neoplasms Carcinoma, Signet Ring Cell Carcinoma, Signet Ring Cell Chemotherapy, Adjuvant Female Humans Male Middle Aged Ovarian Neoplasms Ovarian Neoplasms

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License: CC0 · commercial use OK