The effect of ambulation on vaginal distribution of miconazole nitrate (1200 mg)

Seema Menon, Adrianna Izquierdo, Mark Rosen, Amy Hummel, Kurt Barnhart, Kurt T. Barnhart
Journal of women's health (2002) · 2007 · vol. 16(5) , pp. 703–706 · doi:10.1089/jwh.2006.0163 · PMID:17627405 · W2079326289
Non-randomised trial OA: closed CC0
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This study found that ambulation does not significantly affect the vaginal distribution or dissolution time of a 1200 mg miconazole nitrate insert compared to remaining supine.

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Abstract

OBJECTIVE: To evaluate the effect activity has on the vaginal distribution of a 1200 mg miconazole nitrate gelatin encapsulated insert, an antifungal agent commonly used to treat vaginal vulvocandidiasis. METHOD: Nine subjects underwent two sessions of serial magnetic resonance imaging after insertion of the insert. One session required that the subjects ambulate between images; the other session required the subjects remain supine between images. Vaginal distribution of the insert was quantified by calculating surface contact and linear distance in every image. Comparison of spread was then done between images taken in active subjects and images taken in resting subjects. Time until capsule dissolution was also compared between the two groups. RESULTS: No statistically significant difference was seen in spread of insert between the active and resting group. Activity also had no significant effect on capsule dissolution. CONCLUSION: Activity does not appear to hinder the spread of the insert, suggesting that this medication can be used daytime or nighttime.

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MeSH descriptors

Antifungal Agents Candidiasis, Vulvovaginal Miconazole Vagina Administration, Intravaginal Adult Antifungal Agents Candidiasis, Vulvovaginal Dose-Response Relationship, Drug Female Humans Magnetic Resonance Imaging Miconazole Suspensions Treatment Outcome Vagina Vagina Vaginal Creams, Foams, and Jellies Vaginal Creams, Foams, and Jellies

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License: CC0 · commercial use OK