Pityriasis rubra pilaris, vitamin A and retinol-binding protein: a case study

P C van Voorst Vader, PC Van Voorst Vader, F Van Oostveen, H J Houthoff, Houthoff Hj, J. Marrink
Acta dermato-venereologica · 1984 · vol. 64(5) , pp. 430–432 · doi:10.2340/0001555564430432 · PMID:6208725 · W2409873452
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A case study describes a patient with pityriasis rubra pilaris who failed to respond to vitamin A or danazol therapy despite increased liver vitamin A and elevated serum retinol-binding protein levels.

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This case study describes an adult patient with classical pityriasis rubra pilaris who presented with longstanding erythroderma and decreased sweat secretion. The patient failed to respond to oral megadoses of Vitamin A despite a significant increase in liver vitamin A content, while serum retinol-binding protein levels remained normal. Additionally, treatment with danazol increased retinol-binding protein levels but did not result in any clinical improvement. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

A patient with longstanding erythroderma and decreased sweat secretion due to the classical adult form of pityriasis rubra pilaris is described. The patient did not respond to oral megadoses of Vitamin A, even though a large increase of liver content of Vitamin A was demonstrated. Retinol-binding protein levels in serum of this patient and his relatives were normal. Danazol (Danatrol, Winthrop) therapy caused an increase of retinol-binding protein level, but clinical improvement did not occur.
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Pityriasis rubra pilaris, vitamin A and retinol-binding protein: a case study DOI: https://doi.org/10.2340/0001555564430432Abstract A patient with longstanding erythroderma and decreased sweat secretion due to the classical adult form of pityriasis rubra pilaris is described. The patient did not respond to oral megadoses of Vitamin A, even though a large increase of liver content of Vitamin A was demonstrated. Retinol-binding protein levels in serum of this patient and his relatives were normal. Danazol (Danatrol, Winthrop) therapy caused an increase of retinol-binding protein level, but clinical improvement did not occur.Downloads Downloads Published How to Cite Issue Section License LicenseAll digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work. Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.

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MeSH descriptors

Pityriasis Rubra Pilaris Retinol-Binding Proteins Vitamin A Adult Danazol Danazol Humans Male Pityriasis Rubra Pilaris Pityriasis Rubra Pilaris Retinol-Binding Proteins Vitamin A

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