[Selective progesterone receptor modulators: future clinical applications]

Bouchard P, Philippe Bouchard, Ouzounian S, Sophie Ouzounian, Chabbert-Buffet N, Nathalie Chabbert-Buffet
Bulletin de l'Academie nationale de medecine · 2008 · vol. 192(6) , pp. 1159–71; discussion 1172-3 · doi:10.1016/s0001-4079(19)32715-3 · PMID:19235480
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Selective progesterone receptor modulators (SPRMs) are valuable in women's health, primarily by impacting the endometrium to reduce uterine fibroid volume and bleeding, and are being explored for endometriosis and contraception.

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Abstract

Progesterone antagonists belong to the family of selective progesterone receptor modulators. SPRMs already have several applications in women's health. Their main value lies in their effect on endometrium. For example, they can be used to reduce tumor volume and uterine bleeding before uterine myoma surgery. They are also being evaluated for the treatment of endometriosis, and for estrogen-free contraception.

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Condition tags

endometriosis

MeSH descriptors

Hormone Antagonists Receptors, Progesterone Breast Neoplasms Breast Neoplasms Breast Neoplasms Endometriosis Endometriosis Endometriosis Female Female Hormone Antagonists Hormone Antagonists Hormone Antagonists Humans Humans Leiomyoma Leiomyoma Leiomyoma Molecular Structure Molecular Structure

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europepmc
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