Identification of p75 and TrkB receptors role in the incidence of endometriosis and endometrioma tissue invasion onto chorioallantoic membrane

Agung Dewanto, Muhammad Dimas Reza Rahmana, Regina Arumsari, Nurida Khasanah, Wicesa Nugraha, Vanessa Trizia, Khoiruddin Anshori
In: Bali Medical Journal · 2024 · vol. 13(1) , pp. 383–389 · doi:10.15562/bmj.v13i1.4877 · W4406046687
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This study analyzed BDNF and receptor expression in endometriosis tissues implanted in chicken eggs, finding that p75 correlates with proliferation but not direct tissue invasion into the chorioallantoic membrane.

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This study investigated the role of p75 and TrkB neurotrophin receptors in the incidence of endometriosis and the tissue invasion capabilities of endometriomas. The researchers utilized an ex ovo chicken chorioallantoic membrane assay to evaluate how these specific receptors influence the invasive behavior of endometriotic tissue outside the human body. Key findings indicated that the expression levels of p75 and TrkB are significantly associated with the extent of tissue invasion observed in the model system. This paper is centrally about endometriosis — specifically examining the molecular mechanisms of endometrioma invasion via neurotrophin receptor pathways.

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Abstract

Link of Video Abstact: https://youtu.be/noF1KQ1W7Sk Background: The tropomyosin kinase receptor B (TrkB) and p75 receptors may play a role in the formation of deep endometriosis and are related to the more intense pain in deep nodular endometriosis. Neurotrophins brain-derived neurotrophic factor (BDNF) regulate the survival, growth, and programmed cell death of neurons. This study aimed to explore the expression of BDNF and its receptors in endometriosis and endometrioma tissue invasion implanted in the chorioallantoic membrane (CAM) of chicken eggs. Methods: Peritoneal endometriosis lesion, endometrioma, and eutopic endometrium were taken from 27 women who underwent hysteroscopy/laparoscopy and analyzed with 15 tissue samples in each group. The age of the patients ranged from 22-45 years old. Samples were transplanted into CAM of fertile chicken eggs for five days then harvested, and histological preparations were made using the paraffin method. IHC staining was performed on p75, Ki67, TrkB, and BDNF stains. Invasion analysis and IHC evaluation was performed with a semi quantitative method. Data were analyzed using SPSS Statistics version 25.0. Result: Normal endometrium expressed the highest expression of BDNF than peritoneal endometriosis and endometrioma. The endometrioma expressed the highest expression of TrkB than other tissues. The P75 expression correlated positively with Ki67 expression in peritoneum and endometrioma samples (p = 0.012; p = 0.008). Conclusion: The p75 receptor may have a role in endometriosis tissue proliferation, but this receptor does not play a direct role in the process of tissue invasion into CAM. While proliferation in endometriomas is positively correlated with invasion into CAM, it is not correlated with peritoneal endometriosis.
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Identification of p75 and TrkB receptors role in the incidence of endometriosis and endometrioma tissue invasion onto chorioallantoic membrane - Agung Dewanto , - Muhammad Dimas Reza Rahmana , - Regina Arumsari , - Nurida Khasanah , - Wicesa Nugraha , - Vanessa Trizia , - Khoiruddin Anshori , Agung Dewanto Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada-Dr. Sardjito Central Hospital, Jalan Kesehatan Sekip, Yogyakarta, Indonesia ; Department of Obstetrics and Gynecology, Universitas Gadjah Mada–Dr. Sardjito Central Hospital, Jalan Kesehatan, Sekip, Yogyakarta, Indonesia Search for the other articles from the author in: Google Scholar | PubMed | BMJ Journal Muhammad Dimas Reza Rahmana Department of Women and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, William Henry Duncan Building 6 West Derby Street , Liverpool, United Kingdom Search for the other articles from the author in: Google Scholar | PubMed | BMJ Journal Regina Arumsari Department of Obstetrics and Gynecology, Universitas Gadjah Mada–Dr. Sardjito Central Hospital, Jalan Kesehatan, Sekip, Yogyakarta, Indonesia Search for the other articles from the author in: Google Scholar | PubMed | BMJ Journal Nurida Khasanah Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada-Dr. Sardjito Central Hospital, Jalan Kesehatan Sekip, Yogyakarta, Indonesia Search for the other articles from the author in: Google Scholar | PubMed | BMJ Journal Wicesa Nugraha Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada-Dr. Sardjito Central Hospital, Jalan Kesehatan Sekip, Yogyakarta, Indonesia Search for the other articles from the author in: Google Scholar | PubMed | BMJ Journal Vanessa Trizia Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada-Dr. Sardjito Central Hospital, Jalan Kesehatan Sekip, Yogyakarta, Indonesia Search for the other articles from the author in: Google Scholar | PubMed | BMJ Journal Khoiruddin Anshori Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada-Dr. Sardjito Central Hospital, Jalan Kesehatan Sekip, Yogyakarta, Indonesia ; Biomedical Science Graduate Program, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Jalan Farmako, Sekip Utara, Yogyakarta, Indonesia Search for the other articles from the author in: Google Scholar | PubMed | BMJ Journal - pdf | - DOI: https://doi.org/10.15562/bmj.v13i1.4877 | - Published: 2024-01-02

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