Danazol: objective assessment in the treatment of endometriosis
Non-randomised trial
OA: closed
CC0
⤵ 3 in-corpus citations
AI-generated summary
Danazol therapy at 800 mg daily for 6 months resulted in statistically significant improvement in American Fertility Society scores for endometriosis Stages I and II.
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Abstract
The objective assessment of Danocrine (Danazol, Winthrop) in the treatment of endometriosis was hampered in the 1970s by the absence of a universally accepted classification. The American Fertility Society (AFS) classification, proposed in 1979, has now become widely accepted. However, there is a lack of recorded objective data utilizing the AFS score before and after Danazol therapy. In a series of 51 patients with endometriosis, who underwent laparoscopy, then received Danazol, 800 mg daily for 6 months, and had a repeat laparoscopy, there was a statistically significant improvement in the AFS score in Stage I and II disease.
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Cited by (3)
- Defining a minimal clinically important difference for endometriosis-associated pelvic pain measured on a visual analog scale: analyses of two placebo-controlled, randomized trials 2010
- Development and content validation of two new patient-reported outcome measures for endometriosis: the Endometriosis Symptom Diary (ESD) and Endometriosis Impact Scale (EIS) 2020
- Tissue and endocrine responses to gestrinone and danazol in the treatment of endometriosis 1993
Cited by (3)
- Development and content validation of two new patient-reported outcome measures for endometriosis: the Endometriosis Symptom Diary (ESD) and Endometriosis Impact Scale (EIS) 2020
- Defining a minimal clinically important difference for endometriosis-associated pelvic pain measured on a visual analog scale: analyses of two placebo-controlled, randomized trials 2010
- Tissue and endocrine responses to gestrinone and danazol in the treatment of endometriosis 1993
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- europepmc
- last seen: 2026-10-17T06:09:56.316927+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:21:15.855055+00:00
License: CC0
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