Expression of interleukin-6 and interleukin-6 receptors in human granulosa lutein cells

Christoph Keck, C. Keck, Z Rajabi, Zolfaghar Rajabi, K Pfeifer, K. J. Pfeifer, H Bettendorf, Herta Bettendorf, T Brandstetter, Thomas Brandstëtter, M. Breckwoldt
Molecular human reproduction · 1998 · vol. 4(11) , pp. 1071–1076 · doi:10.1093/molehr/4.11.1071 · PMID:9835360 · W2098256963
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This study found that human granulosa lutein cells express interleukin-6 and its receptor, and that IL-6 inhibits HCG-induced progesterone secretion from these cells.

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Abstract

Cytokines are important regulators of reproductive functions. Significant amounts of interleukin-6 (IL-6) have been detected in the serum and ascites of patients with ovarian hyperstimulation syndrome (OHSS). These findings suggest the involvement of IL-6 as a mediator in the pathogenesis of OHSS. This study was performed to analyse IL-6 and IL-6 receptor (IL-6-R) expression in human granulosa lutein cells (GC). GC were cultured after isolation from follicular fluid. IL-6 concentrations in follicular fluid and serum from individual patients and GC supernatants were measured by enzyme-linked immunosorbent assay. We found detectable concentrations of IL-6 in serum and follicular fluid of all patients. Expression of IL-6 in GC was shown immunocytochemically. IL-6 mRNA was detected in GC by in-situ hybridization. Gene expression for IL-6 and IL-6-R in GC was demonstrated using reverse transcription-polymerase chain reaction. IL-6 significantly inhibited human chorionic gonadotrophin (HCG)-induced progesterone secretion of GC. The results of our study suggest that IL-6 is expressed in HGC and that this cytokine is able to modulate GC function via its specific receptor. This is the first report that describes the precence of IL-6-R in human granulosa lutein cells.

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MeSH descriptors

Granulosa Cells Interleukin-6 Receptors, Interleukin-6 Cells, Cultured Enzyme-Linked Immunosorbent Assay Female Gene Expression Regulation Granulosa Cells Humans Interleukin-6 Interleukin-6 Polymerase Chain Reaction Receptors, Interleukin-6 Receptors, Interleukin-6

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SciLite annotations

organisms 4
human human human human
chemicals 1
progesterone

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