Racial Differences in the Association of Endometriosis and Uterine Leiomyomas With the Risk of Ovarian Cancer
article
OA: green
CC0
⤵ 3 in-corpus citations
AI-generated summary
Endometriosis increased ovarian cancer risk for Black and White individuals, with hysterectomy modifying this association in White participants, while leiomyomas elevated ovarian cancer risk in both races, with hysterectomy modifying the risk in both.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
OBJECTIVE: To evaluate associations between endometriosis and uterine leiomyomas with ovarian cancer risk by race and the effect of hysterectomy on these associations. METHODS: We used data from four case-control studies and two case-control studies nested within prospective cohorts in the OCWAA (Ovarian Cancer in Women of African Ancestry) consortium. The study population included 3,124 Black participants and 5,458 White participants, of whom 1,008 Black participants and 2,237 White participants had ovarian cancer. Logistic regression was used to calculate odds ratios (ORs) and 95% CIs for the associations of endometriosis and leiomyomas with ovarian cancer risk, by race, stratified by histotype and hysterectomy. RESULTS: The prevalences of endometriosis and leiomyomas were 6.4% and 43.2% among Black participants and 7.0% and 21.5% among White participants, respectively. Endometriosis was associated with an increased risk of endometrioid and clear-cell ovarian cancer in both racial groups (eg, OR for endometrioid tumors for Black and White participants 7.06 [95% CI 3.86-12.91] and 2.17 [95% CI 1.36-3.45], respectively, Phetereogeneity =.003). The association between endometriosis and ovarian cancer risk in White participants was stronger in those without hysterectomy, but no difference was observed in Black participants (all Pinteraction ≥.05). Leiomyomas were associated with an elevated risk of ovarian cancer only in those without hysterectomy in both Black (OR 1.34, 95% CI 1.11-1.62) and White (OR 1.22, 95% CI 1.05-1.41) participants (all Pinteraction ≥.05). CONCLUSIONS: Black and White participants with endometriosis had a higher risk of ovarian cancer, and hysterectomy modified this association among White participants. Leiomyomas were associated with an increased risk of ovarian cancer in both racial groups, with hysterectomy modifying the risk in both groups. Understanding how racial differences in access to care and treatment options (eg, hysterectomy) may help guide future risk reduction strategies.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (38)
- Chronic gynecological conditions reported by US women: findings from the National Health Interview Survey, 1984 to 1992. via openalex
- Disparity in endometriosis diagnoses between racial/ethnic groups via openalex
- Endometriosis and menopausal hormone therapy impact the hysterectomy-ovarian cancer association via openalex
- Endometriosis: cost estimates and methodological perspective via openalex
- Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries via openalex
- Incidence of endometrioid and clear-cell ovarian cancer in histological proven endometriosis: the ENOCA population-based cohort study via openalex
- Incidence of endometriosis by study population and diagnostic method: the ENDO study via openalex
- Influence of race/ethnicity on prevalence and presentation of endometriosis: a systematic review and meta‐analysis via openalex
- Modeling of medical and surgical treatment costs of chronic pelvic pain: new paradigms for making clinical decisions. via openalex
- Non-health-care costs associated with endometriosis via openalex
- Oral contraceptive use, reproductive history, and risk of epithelial ovarian cancer in women with and without endometriosis via openalex
- Ovarian Cancer Risk Factors by Histologic Subtype: An Analysis From the Ovarian Cancer Cohort Consortium via openalex
- Rate of hospitalization for gynecologic disorders among reproductive-age women in the United States via openalex
- Relationship of Benign Gynecologic Diseases to Subsequent Risk of Ovarian and Uterine Tumors via openalex
- The Association Between Hysterectomy and Ovarian Cancer Risk: A Population-Based Record-Linkage Study via openalex
- The epidemiology of endometriosis via openalex
- W2741175453 via openalex
- W2778696431 via openalex
- W2791921535 via openalex
- W2954378910 via openalex
- W4212838134 via openalex
- W19931880 via openalex
- W6606528098 via openalex
- W1784175517 via openalex
- W1969018878 via openalex
- W1973438143 via openalex
- W1975499742 via openalex
- W1986768904 via openalex
- W1988990531 via openalex
- W2005441291 via openalex
- W2114647004 via openalex
- W2125681453 via openalex
- W2149783974 via openalex
- W2264069562 via openalex
- W2307535985 via openalex
- W2588229802 via openalex
- W2595206985 via openalex
- W2606888643 via openalex
Cited by (3)
Source provenance
- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-06-04T00:33:56.134770+00:00
License: CC0
· commercial use OK