Macrophage Immune Memory Controls Endometriosis in Mice and Humans

Mohamed Jeljeli, Luiza Gama Coelho Riccio, Luiza G C Riccio, Sandrine Chouzenoux, Fabiana Moresi, Laurie Toullec, Ludivine Doridot, Carole Nicco, Mathilde Bourdon, Louis Marcellin, Piétro Santulli, Pietro Santulli, Mauricio S Abrão, Maurício Simões Abrão, Charles Chapron, Frédéric Batteux
Cell reports · 2020 · vol. 33(5) , pp. 108325 · doi:10.1016/j.celrep.2020.108325 · PMID:33147452 · W3085811702
article OA: gold CC0 ⤵ 44 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

Tolerized human macrophages, via IL-10, mitigate endometriosis, and prior Gram-negative infections are linked to improved outcomes in patients.

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Abstract

-tolerized human macrophages mitigate the fibro-inflammatory phenotype of endometriotic cells in an interleukin-10 (IL-10)-dependent manner. A history of severe Gram-negative infection is associated with reduced infertility duration and alleviated symptoms, in contrast to patients with Gram-positive infection history. Thus, the manipulation of innate immune memory may be effective in dampening hyper-inflammatory conditions, opening the way to promising therapeutic approaches.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Immunologic Memory Macrophages, Peritoneal Adoptive Transfer Animals Coculture Techniques Cytokines Cytokines Endometriosis Endometriosis Female Gram-Negative Bacterial Infections Gram-Negative Bacterial Infections Humans Immune Tolerance Lipopolysaccharides Macrophages, Peritoneal Mice Phenotype

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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