Rapid dissolution of high-potency danazol particles produced by evaporative precipitation into aqueous solution

Xiaoxia Chen, Jason M. Vaughn, Miguel José Yacamán, Miguel J Yacaman, Robert O. Williams, Keith P. Johnston
Journal of pharmaceutical sciences · 2004 · vol. 93(7) , pp. 1867–1878 · doi:10.1002/jps.20001 · PMID:15176074 · W2070875511
Lab / animal OA: closed CC0 ⤵ 4 in-corpus citations
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Evaporative precipitation into aqueous solution rapidly produced high-potency danazol particles with improved dissolution properties.

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Abstract

High-potency danazol particles with high dissolution rates were produced by evaporative precipitation into aqueous solution (EPAS). Aqueous suspensions formed by EPAS were centrifuged to remove the nonadsorbed surfactant. The resulting surfactant-coated drug particles had extremely high drug-to-surfactant ratios greater than 5, corresponding to potencies (wt drug/wt drug + wt surfactant) as high as 93%. The mechanism of the high dissolution rates was characterized as a function of surfactant adsorption, particle size and surface area, drug crystallinity, and the contact angle for water on the drug surface. For danazol stabilized by polyvinyl pyrrolidone (PVP) alone or with sodium lauryl sulfate (SLS), small particle diameter and high surface area led to high dissolution rates with approximately 90% drug dissolved in 2 min. The crystallinity of the danazol was typically 80%. The properties of the particles and the dissolution rates were mostly unchanged under a 2-week thermal cycling stress test.

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MeSH descriptors

Danazol Danazol Water Water Chemical Precipitation Danazol Particle Size Pharmaceutical Solutions Pharmaceutical Solutions Pharmaceutical Solutions Phase Transition Solubility Solubility Water

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