Serum metabolome and gut microbiome to analyze potential mechanisms of catamenial epilepsy

Yujie Chen, Yiting Deng, Enhui Zhang, Nanya Hao, Zhujing Ou, Raowei Yan, Rui Yan, Muke Zhou, Hesheng Zhang, Dong Zhou, Xintong Wu
Epilepsy & behavior : E&B · 2025 · vol. 174 , pp. 110808 · doi:10.1016/j.yebeh.2025.110808 · PMID:41275703 · W4416625005
Observational OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-11 ⓘ

This study investigated the interplay between serum metabolomics and gut microbiome composition to elucidate potential underlying mechanisms of catamenial epilepsy.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

BACKGROUND: Catamenial epilepsy (CE) is marked by an increase in seizure frequency during specific phases of the menstrual cycle. Advanced techniques such as serum metabolomics and 16S rRNA sequencing are being employed to investigate potential mechanisms and therapeutic approaches for managing CE. METHODS: A total of 30 epilepsy patients (15 with CE and 15 temporal epilepsy) along with 15 healthy controls, were enrolled in this study. Human fecal samples and serum were collected for metabolomics analysis and 16S rDNA sequencing, respectively. RESULTS: A total of 117 candidate metabolites and eight gut microbiota specific to CE were identified. Glycerophospholipid pathways were the most enriched among the candidate metabolites. Notably, serum lysophosphatidylinositol (LPI) 20:4 was associated with an increased seizure frequency. Additionally, differential gut metabolites were found to affect γ-aminobutyric acid degradation. A network linking sex hormones, metabolites, and gut microorganisms was constructed. CONCLUSION: Findings clarify metabolite-microbiome-brain axis interactions, aiding CE pathogenesis understanding.

My notes (saved in your browser only)

MeSH descriptors

Epilepsy Epilepsy Epilepsy Epilepsy Gastrointestinal Microbiome Gastrointestinal Microbiome Metabolome Metabolome Adult Feces Feces Female Humans Metabolomics RNA, Ribosomal, 16S RNA, Ribosomal, 16S Young Adult

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (1)

References (61)

Source provenance

openalex
last seen: 2026-05-11T05:49:40.447239+00:00
pubmed
last seen: 2026-10-08T21:52:40.663774+00:00
unpaywall
last seen: 2026-10-18T06:28:46.490043+00:00
License: CC0 · commercial use OK