Vascular endothelial growth factor gene polymorphisms in Korean patients with premature ovarian failure

Young Joo Jeon, Youngsok Choi, Sung Han Shim, Yi Seul Choi, Jung Jae Ko, Tae Ki Yoon, Sun Hee Cha, Sun Hee, Nam Keun Kim
European journal of obstetrics, gynecology, and reproductive biology · 2011 · vol. 159(1) , pp. 138–142 · doi:10.1016/j.ejogrb.2011.07.007 · PMID:21831507 · W2168982379
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This study investigated the association between vascular endothelial growth factor gene polymorphisms and premature ovarian failure in Korean patients.

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Abstract

OBJECTIVE: To study the association of vascular endothelial growth factor (VEGF) polymorphisms (-2578C>A, -1154G>A, -634G>C, and 936C>T) with premature ovarian failure (POF) in Korean patients. STUDY DESIGN: Prospective case-control study. One hundred and thirty five patients with POF and confirmed serum follicle-stimulating hormone levels of >40IU/L before the age of 40 years and 120 healthy controls with at least one live birth, regular menstrual cycles, and karyotype 46, XX. RESULTS: POF patients exhibited significantly different frequencies of the VEGF -1154GA genotype (odds ratio [OR], 2.002; 95% confidence interval [CI], 1.116-3.592; P=0.019), and -2578CA+AA/-1154GA+AA combination genotype (OR, 1.805; 95% CI, 1.013-3.217; P=0.044) compared to the control group. The frequency of the -2578A/-1154A haplotype (OR, 1.647; 95% CI, 1.017-2.677; P=0.041) was significantly higher in the POF group than in the control group. CONCLUSION: The VEGF -1154G>A mutation, -2578CA+AA/-1154GA+AA combination genotype, and -2578A/-1154A haplotype are significantly associated with POF in Korean women.

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MeSH descriptors

Polymorphism, Genetic Primary Ovarian Insufficiency Vascular Endothelial Growth Factor A Adult Alleles Case-Control Studies Female Follicle Stimulating Hormone, Human Follicle Stimulating Hormone, Human Gene Frequency Genetic Association Studies Haplotypes Humans Mutation Polymorphism, Single Nucleotide Primary Ovarian Insufficiency Primary Ovarian Insufficiency Promoter Regions, Genetic Prospective Studies Republic of Korea

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