The importance of activity and pretreatment in the prevention of suxamethonium myalgias

D C Oxorn, Donald C. Oxorn, George S. Whatley, G S Whatley, J W Knox, J. W. D. Knox, James W. Hooper, J Hooper
British journal of anaesthesia · 1992 · vol. 69(2) , pp. 200–201 · doi:10.1093/bja/69.2.200 · PMID:1389827 · W2092502233
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In vaginal hysterectomy patients, pretreatment with atracurium significantly reduced postoperative myalgias compared to placebo, while increased activity levels were observed on the second postoperative day.

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Abstract

We have studied the effectiveness of pretreatment with atracurium 0.05 mg kg-1 and placebo before administration of suxamethonium, in the prevention of postoperative myalgia in inpatients having surgery in which rapid postoperative mobilization was possible (vaginal hysterectomy). On the second day after operation, the patients pretreated with atracurium had significantly fewer postoperative myalgias than those receiving placebo (P < 0.025). All patients were significantly more active on the second day compared with the first day after operation (P < 0.025). Possible causal relationships are discussed.

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MeSH descriptors

Atracurium Muscular Diseases Postoperative Pain Premedication Succinylcholine Adult Atracurium Female Humans Hysterectomy, Vaginal Middle Aged Muscular Diseases Muscular Diseases Postoperative Pain Postoperative Pain Succinylcholine

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