Expression of Steroidogenic Factor 1 (SF-1) and Steroidogenic Acute Regulatory Protein (StAR) in Endometriosis is Associated with Endometriosis Severity

Yongjie Tian, Ye Tian, B Kong, Beihua Kong, W Zhu, Wengen Zhu, S Su, Shan Su, Y Kan, Yuen‐Yee Kan
The Journal of international medical research · 2009 · vol. 37(5) , pp. 1389–1395 · doi:10.1177/147323000903700513 · PMID:19930843 · W2091376942
article OA: bronze CC0 ⤵ 13 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study found that steroidogenic factor 1 (SF-1) and steroidogenic acute regulatory protein (StAR) are upregulated in ectopic endometriotic tissues and associated with endometriosis severity.

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Abstract

This study was designed to investigate the levels of expression of steroidogenic factor 1 (SF-1) and steroidogenic acute regulatory protein (StAR) in endometriosis, and to explore the association between these two factors and the menstrual cycle and the severity of endometriosis. Levels of SF-1 and StAR protein were evaluated using immunohistochemistry in 38 cases of endometriosis with ectopic endometria and in 25 normal endometria (controls). The SF-1 and StAR protein levels were significantly higher in ectopic endometria than in normal endometria. There was a significant correlation between the level of SF-1 and StAR in ectopic endometriotic tissues. It is concluded that protein levels of SF-1 and StAR are upregulated in ectopic endometria and are significantly correlated with the severity of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometrium Ovarian Neoplasms Peritoneal Neoplasms Phosphoproteins Steroidogenic Factor 1 Adult Case-Control Studies Endometriosis Endometriosis Endometrium Endometrium Female Humans Immunoenzyme Techniques Ovarian Neoplasms Ovarian Neoplasms Peritoneal Neoplasms Peritoneal Neoplasms Phosphoproteins

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (13)

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