Serum activity of matrix metalloproteinases -2 and -9

G. M. Soboleva; A. V. Shurshalina; G T Sukhikh; Г. Т. Сухих

doi:10.1007/s10517-006-0140-1

Serum activity of matrix metalloproteinases -2 and -9

G. M. Soboleva, A. V. Shurshalina, G T Sukhikh, Г. Т. Сухих

Bulletin of experimental biology and medicine · 2006 · vol. 141(2) , pp. 247–249 · doi:10.1007/s10517-006-0140-1 · PMID:16984109 · W1977010329

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Serum activities of matrix metalloproteinases-2 and -9 are decreased in chronic endometritis associated with sterility, normalize after recovery, and may serve as markers for monitoring treatment efficiency.

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Abstract

Matrix metalloproteinases belong to the key effectors of tissue remodeling in health and disease. Matrix metalloproteinases -2 and -9, the most prevalent representatives of this family, are expressed in the endometrium. Chronic endometritis concomitant with sterility and spontaneous abortions is associated with decreased content of matrix metalloproteinases in the endometrium. Chronic endometritis combined with sterility correlates with decreased serum activities of matrix metalloproteinases -2 and -9, which returns to normal after recovery. Measurements of serum activities of matrix metalloproteinases -2 and -9 are proposed for monitoring of the dynamics and treatment efficiency in chronic endometritis.

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MeSH descriptors

Endometritis Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Abortion, Habitual Abortion, Habitual Abortion, Habitual Adult Case-Control Studies Chronic Disease Embryo Implantation Embryo Implantation Endometritis Endometritis Female Humans Infertility, Female Infertility, Female Infertility, Female Matrix Metalloproteinase 2 Matrix Metalloproteinase 9

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Cites (1)

Matrix metalloproteinase 2 is associated with changes in steroid hormones in the sera and peritoneal fluid of patients with endometriosis 2004

References (14)

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[1] Matrix metalloproteinase 2 is associated with changes in steroid hormones in the sera and peritoneal fluid of patients with endometriosis 2004