PECULIARITIES OF HORMONAL HOMEOSTASIS IN WOMEN WITH ENDOMETRIOSIS ASSOCIATED WITH INFERTILITY

Оксана Бакун, I. O. Tsumanets, V. G. Kupchanko
In: Clinical & experimental pathology · 2016 · vol. 15(2) · doi:10.24061/1727-4338.xv.2.56.2016.6 · W2903804484
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This study analyzed hypophysial hormone concentrations in women with endometriosis-associated infertility during the menstrual cycle and superovulation, finding significant disturbances in gonadotrophin secretion rhythms proportional to disease severity.

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This study investigated the concentration of pituitary hormones in the blood of women suffering from endometriosis associated with infertility. Measurements were taken on days two to three of the menstrual cycle and on the day of ovarian puncture during superovulation stimulation cycles. The researchers identified significant disruptions in the normal rhythm and content of gonadotropin secretion among these patients, noting that these abnormalities were proportional to the severity of the disease. This paper is centrally about endometriosis — specifically examining hormonal homeostasis and gonadotropin disturbances in women with endometriosis-associated infertility.

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Abstract

The study has been devoted to the concentration of hypophysial hormones in women’s blood with endometriosis associated withinfertility women’s blood on the second-third days of menstrual cycle and on the day of paracentesis of the ovary in the cycle of stimulating superovulation. Significant disturbances of the normal rhythm secretion and gonadotrophic hormones contents in the blood proportional to the degree of illness gravity were determined in women with endometriosis associated with infertility.
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ОСОБЛИВОСТІ ГОРМОНАЛЬНОГО ГОМЕОСТАЗУ В ЖІНОК З ЕНДОМЕТРІОЗОМ, АСОЦІЙОВАНИМ ІЗ БЕЗПЛІДДЯМ DOI: https://doi.org/10.24061/1727-4338.XV.2.56.2016.6Ключові слова: гіпофізарні гормони, лютропін, фолітропін, безпліддя, ендометріозАнотація Робота присвячена вивченню концентрації гіпофізарних гормонів у крові жінок з ендометріозом, асоційованим із безпліддям на 2-3-й день менструального циклу та в день пункції яєчника в циклі стимуляції суперовуляції. У хворих з ендометріозом, асоційованим із безпліддям виявлені значні порушення нормального ритму секреції та вмісту в крові гонадотропних гормонів, які є пропорційними щодо ступеня тяжкості захворювання. Посилання Vdovychenko YuP, Vitiuk AD. Likuvannia anovuliatornoho bezpliddia za naiavnosti hormonal'no-imunolohichnykh porushen' [Treatment of anovulatory infertility in the presence of hormonal and immunological disorders]. Zdorov'e zhenshchiny. 2011;8:180-83. (in Ukrainian). Vorobii VD. Reproduktyvne zdorov’ia zhinok iz henital'nym endometriozom [Reproductive health of women with genital endometriosis]. Zdorov'e zhenshchiny.. 2011;6:161-62. (in Ukrainian). Bozhenko OIu. Anhiohenez pry dobroiakisnykh ta zloiakisnykh pukhlynakh yaiechnykiv: osoblyvosti peredoperatsiinoi diahnostyky [Angiogenesis in benign and malignant ovarian tumors: features of preoperative diagnosis]. Mezhdunarodnyy zhurnal pediatrii, akusherstva i ginekologii. 2013;3(2):88-93. (in Ukrainian). Huhtinen K, Desai R, Ståhle M, Salminen A, Handelsman DJ, Perheentupa A, et al. Endometrial and endometriotic concentrations of estrone and estradiol are determined by local metabolism rather than circulating levels. J Clin Endocrinol Metab. 2012 Nov;97(11):4228-35. DOI:10.1210/jc.2012-1154. Kornatskaya AG, Reven'ko OA, Danilenko EG, Chubey GV. Sindrom khronicheskoy tazovoy boli: vzglyad ginekologa [Syndrome of chronic pelvic pain: gynecologist's view]. Zdorov'e zhenshchiny.2012;6:35-40. (in Russian). Endometrioz: diagnostika, lechenie i reabilitatsiya [Endometriosis: diagnosis, treatment and rehabilitation]. Federal'nye klinicheskie rekomendatsii po vedeniyu bol'nykh. Moskva; 2013. 65 s. (in Russian). Kristensen SL, Ramlau-Hansen CH, Andersen CY, Ernst E, Olsen SF, Bonde JP, et al. The association between circulating levels of antimullerian hormone and follicle number, androgens, and menstrual cycle characteristics in young women. Fertil Steril. 2012 Mar;97(3):779-85. DOI:10.1016/j.fertnstert.2011.12.017. ##submission.downloads## Опубліковано Номер Розділ Ліцензія Авторське право (c) 2018 O. V. Bakun, I. O. Tsumanets, V. G. Kupchanko Ця робота ліцензується відповідно до Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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endometriosisinfertility

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