SPATIAL MEMORY RECOVERY IN AGED MALE RATS TREATED WITH LEUPROLIDE ACETATE, A GNRH AGONIST

M Macedo-Mendoza, Macedo-Mendoza M, Calderón-Vallejo D, D Calderón-Vallejo, González-Torres ML, M L González-Torres, Martínez-Martínez A, A Martínez-Martínez, D Gasca-Martínez, Gasca-Martínez D, Orta Salazar EM, E M Orta Salazar, Quintanar JL, J L Quintanar
Acta endocrinologica (Bucharest, Romania : 2005) · 2024 · vol. 20(2) , pp. 127–135 · doi:10.4183/aeb.2024.127 · PMID:39845751 · PMC11750219
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Leuprolide acetate treatment improved spatial memory and increased hippocampal spinophilin and MAP2 expression in aged intact male rats, indicating potential for cognitive restoration.

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This study investigated the effects of leuprolide acetate, a GnRH agonist, on spatial memory and hippocampal plasticity in aged intact male rats. Researchers administered the drug every three days for nine weeks and evaluated cognitive performance using the Morris Water Maze and Y-maze tests alongside protein expression analysis. The results demonstrated that leuprolide acetate improved spatial memory and increased the expression of spinophilin and MAP2 in the hippocampus compared to saline controls. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

CONTEXT: Studies indicate a decrease in spatial memory across species as they age. Moreover, consistent administration of Gonadotropin-releasing hormone (GnRH) improves learning abilities in older rats that have undergone gonadectomy. OBJECTIVE: The aim of this study was to investigate the effects of the GnRH agonist, leuprolide acetate (LA) on spatial memory in aged intact male rats and the expression of proteins associated with hippocampal plasticity. SUBJECTS AND METHODS: Aged male rats were injected with LA or saline every three days for nine weeks to assess the effects of LA on spatial memory. The aged rats were trained in the Morris Water Maze for four days, and the evaluation took place on the fifth day. Additionally, the Y-maze test was used to investigate short-term spatial memory. The expression of spinophilin and microtubule-associated protein 2 (MAP2) in the hippocampus was measured. RESULTS: Behavioral tests revealed that LA improves spatial memory in aged rats. Additionally, we observed increased expression of spinophilin and MAP2 in the hippocampus of aged male rats following LA treatment. Based on these results, the administration of LA holds is a potential treatment for restoring cognitive function in aged individuals.
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- Login - Register - Home/Current Issue - About the journal - Editorial board - Online submission - Instructions for authors - Subscriptions - Foundation Acta Endocrinologica - Archive - Contact Romanian Academy The Publishing House of the Romanian Academy ACTA ENDOCRINOLOGICA (BUC) The International Journal of Romanian Society of Endocrinology / Registered in 1938in Web of Science Master Journal List Acta Endocrinologica(Bucharest) is live in PubMed Central Journal Impact Factor - click here. This Article Services Google Scholar PubMed Acta Endocrinologica (Buc) Macedo-Mendoza M, Calderon-Vallejo D, González-Torres ML, Martinez-Martinez A, Gasca-Martinez D, Orta Salazar EM, Quintanar JL Spatial Memory Recovery in Aged Male Rats Treated with Leuprolide Acetate, a GnRH Agonist Acta Endo (Buc) 2024, 20 (2): 127-135doi: 10.4183/aeb.2024.127 Context. Studies indicate a decrease in spatial memory across species as they age. Moreover, consistent administration of Gonadotropin-releasing hormone (GnRH) improves learning abilities in older rats that have undergone gonadectomy. Objective. The aim of this study was to investigate the effects of the GnRH agonist, leuprolide acetate (LA) on spatial memory in aged intact male rats and the expression of proteins associated with hippocampal plasticity. Subjects and methods. Aged male rats were injected with LA or saline every three days for nine weeks to assess the effects of LA on spatial memory. The aged rats were trained in the Morris Water Maze for four days, and the evaluation took place on the fifth day. Additionally, the Y-maze test was used to investigate short-term spatial memory. The expression of spinophilin and microtubule-associated protein 2 (MAP2) in the hippocampus was measured. Results. Behavioral tests revealed that LA improves spatial memory in aged rats. Additionally, we observed increased expression of spinophilin and MAP2 in the hippocampus of aged male rats following LA treatment. Based on these results, the administration of LA holds is a potential treatment for restoring cognitive function in aged individuals. Keywords: Gonadotropin releasing-hormone agonist, Hippocampus, Spinophilin, MAP2, Morris water maze. Correspondence: J. Luis Quintanar. Depto. de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Av. Universidad 940 C.P. 20100, Col. Ciudad Universitaria, Aguascalientes Ags., México, E-mail: [email protected]

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