Polymorphism and pelvic organ prolapse: combining strict inclusion criteria and environmental risk factors as a good standard for further studies

This paper discusses methodological standards for future research on the relationship between genetic polymorphisms and pelvic organ prolapse, emphasizing the necessity of combining strict inclusion criteria with environmental risk factors. It highlights the importance of rigorous study design to accurately identify potential genetic associations while accounting for external influences on disease development. The authors argue that these combined approaches provide a more robust foundation for subsequent investigations into the etiology of pelvic floor disorders. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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