Comparison of antiproliferative effects of metformine and progesterone on estrogen-induced endometrial hyperplasia in rats

Mustafa Taş, Mustafa Tas, Mehmet Serdar Kutuk, Mehmet Serdar Kütük, İbrahim Serdar Serin, Mahmut Tuncay Ozgun, Mahmut Tuncay Özgün, Gökalp Öner, Gokalp Oner, Figen Ozturk, Figen Öztürk
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2013 · vol. 29(4) , pp. 311–314 · doi:10.3109/09513590.2012.743010 · PMID:23305503 · W1981782811
Lab / animal OA: closed CC0 ⤵ 3 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Metformin and medroxyprogesterone acetate comparably attenuated estrogen-induced endometrial hyperplasia and uterotrophy in oophorectomized rats.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Metformin has been shown to inhibit the growth of endometriotic implants, and reverse endometrial hyperplasia when combined with oral contraceptive in a case report. The aim of this study is to compare the antiproliferative effects of medroxyprogesterone acetate (MPA), and metformin in oopherectomized rat endometrium. Forty oopherectomized Wistar-Albino rats were used, and assigned to receive saline, 17 β Estradiol hemihydrate (4 mg/kg), 17 β Estradiol hemihydrate (4 mg/kg) and metformin (50 mg/kg), 17 β Estradiol hemihydrate (4 mg/kg) and MPA (1 mg/day) for 14 days. Histological markers of uterotrophy, including endometrial height, luminal ephitelial cell height and density of endometrial glands on hysterectomy speciments were quantified for each specimen. Rats treated with estradiol had significantly increased in endometrial height, endomerial luminal epithelial height and endometrial gland densitiy than the other groups. Metformin and MPA acetate significantly reduced all parameters indicating endometrial hyperplasia, and uterotrophy with respect to the control group. Antiproliferative effects of metformin, and MPA was found to be comparable for all three parameters. In conclusion, metformin attenuates estrogen-induced endometrial hyperplasia in ooferectomized rats to the same degree as progesterone.

My notes (saved in your browser only)

MeSH descriptors

Cell Proliferation Endometrial Hyperplasia Endometrium Metformin Progesterone Animals Cell Proliferation Endometrial Hyperplasia Endometrial Hyperplasia Endometrial Hyperplasia Endometrium Endometrium Estradiol Female Metformin Metformin Progesterone Progesterone Rats Rats, Wistar

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (4)

Cited by (3)

References (35)

Cited by (3)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:11:19.299510+00:00
unpaywall
last seen: 2026-10-16T06:24:35.758740+00:00
License: CC0 · commercial use OK