Treatment of autonomous ovarian follicular cyst with long-term anastrozole therapy

Ozlem Engiz, Özlem Engiz, Merih Berberoglu, Merih Berberoğlu, Zeynep Şıklar, Zeynep Siklar, Pelin Bilir, Gonul Ocal, Gönül Öçal
The Indian Journal of Pediatrics · 2009 · vol. 76(9) , pp. 950–951 · doi:10.1007/s12098-009-0190-2 · PMID:19904510 · W2092666357
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Anastrozole successfully treated a recurrent autonomous ovarian follicular cyst in a girl with peripheral precocious puberty without adverse reactions, demonstrating its safety and tolerability for suppressing estrogen action.

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Abstract

Functional follicular ovarian cysts are frequently reported in girls with peripheral precocious puberty (PP). These cysts are usually self-limiting and resolve spontaneously. Several drugs like antiestrogens (tamoxifen) and new aromatase inhibitors are seldom used for treatment. Here we report a girl with peripheral PP who presented with unilateral enlargement of the ovary and a recurrent autonomous ovarian cyst. No skin pigmentation or bone anomaly was noted. The patient was successfully treated with anastrozole, a highly selective aromatase inhibitor. No adverse reaction was noted. Anastrozole is a safe and tolerable drug especially used to suppress estrogen action.

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MeSH descriptors

Aromatase Inhibitors Nitriles Ovarian Cysts Triazoles Anastrozole Aromatase Inhibitors Child Female Humans Nitriles Ovarian Cysts Puberty, Precocious Puberty, Precocious Recurrence Triazoles

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