Disappearance of steroid hormone dependency during malignant transformation of ovarian clear cell cancer
Akahane T,
Tomoko Akahane,
Sekizawa A,
Akihiko Sekizawa,
Tsuyoshi Okuda,
Okuda T,
Miki Kushima,
Kushima M,
Hiroshi Saito,
Saito H,
Takashi Okai,
Okai T
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This study observed a gradual reduction in estrogen and progesterone receptor expression during malignant transformation from endometriosis to ovarian clear cell carcinoma, suggesting a loss of hormone dependency.
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by qwen3.7-flash, 2026-08-25
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This study examined the immunohistochemical expression of steroid hormone receptors and cancer-related genes in ovarian clear cell carcinoma (OCCA) and endometrioid carcinoma specimens that contained concurrent endometriosis or atypical endometriosis. The researchers identified pathological progression from benign endometriosis to malignancy in a subset of cases and tracked changes in estrogen receptor alpha and progesterone receptor A levels throughout this transition. They found that OCCA development was associated with a gradual reduction in both ERα and PRA expression, whereas ERα expression increased during the transformation to endometrioid carcinoma. This paper is centrally about endometriosis — specifically its malignant transformation into ovarian clear cell carcinoma and the associated loss of steroid hormone dependency.
Abstract
Ovarian clear-cell carcinoma (OCCA) and ovarian endometrioid carcinoma (OEMC) are often associated with endometriosis. This study determined the immunohistochemical expression of steroid hormone receptors and cancer-related genes in OCCA and OEMC specimens containing endometriosis and atypical endometriosis. Pathological progression from endometriosis to atypical endometriosis to carcinoma was identified in 4 of 22 OCCAs and 4 of 16 OEMCs. Using paraffin-embedded tissue samples, expression and changes in expression for estrogen receptors (ERs) and progesterone receptors (PRs) were examined in relation to the observed pathological changes. A gradual reduction in ERalpha and PRA expression was observed with malignant transformation from endometriosis to atypical endometriosis to OCCA. In OEMC, ERalpha expression increased with malignant transformation. In conclusion, reductions in ERalpha and PRA expression were observed with progression from endometriosis to atypical endometriosis in OCCA specimens. Disappearance of hormone dependency might therefore be associated with malignant transformation to OCCA.
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Disappearance of Steroid Hormone Dependency During Malignant Transformation of Ovarian Clear Cell Cancer
- Tomoko Akahane
- Akihiko Sekizawa
- Tsuyoshi Okuda
- Miki Kushima
- Hiroshi Saito
- Takashi Okai
Summary:
Ovarian clear-cell carcinoma (OCCA) and ovarian endometrioid carcinoma (OEMC) are often associated with endometriosis. This study determined the immunohistochemical expression of steroid hormone receptors and cancer-related genes in OCCA and OEMC specimens containing endometriosis and atypical endometriosis. Pathological progression from endometriosis to atypical endometriosis to carcinoma was identified in 4 of 22 OCCAs and 4 of 16 OEMCs. Using paraffin-embedded tissue samples, expression and changes in expression for estrogen receptors (ERs) and progesterone receptors (PRs) were examined in relation to the observed pathological changes. A gradual reduction in ERα and PRA expression was observed with malignant transformation from endometriosis to atypical endometriosis to OCCA. In OEMC, ERα expression increased with malignant transformation. In conclusion, reductions in ERα and PRA expression were observed with progression from endometriosis to atypical endometriosis in OCCA specimens. Disappearance of hormone dependency might therefore be associated with malignant transformation to OCCA.
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Condition tags
endometriosis
MeSH descriptors
Adenocarcinoma, Clear Cell
Adenocarcinoma, Clear Cell
Ovarian Neoplasms
Ovarian Neoplasms
Receptors, Estrogen
Receptors, Progesterone
Adenocarcinoma, Clear Cell
Adenocarcinoma, Clear Cell
Animals
Animals
Antibodies, Monoclonal
Antibodies, Monoclonal
Cell Transformation, Neoplastic
Cell Transformation, Neoplastic
Endometriosis
Endometriosis
Endometriosis
Erb-b2 Receptor Tyrosine Kinases
Erb-b2 Receptor Tyrosine Kinases
Erb-b2 Receptor Tyrosine Kinases
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Source provenance
- europepmc
- last seen: 2026-10-15T06:08:49.021275+00:00
- pubmed
- last seen: 2026-10-08T21:03:24.829172+00:00
- unpaywall
- last seen: 2026-10-15T06:24:24.424788+00:00
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Courtesy of the U.S. National Library of Medicine