Transmission of naturally occurring lymphoma in macaque monkeys

R D Hunt, Hunt RD, B J Blake, Blake BJ, L V Chalifoux, Chalifoux LV, P K Sehgal, Sehgal PK, N W King, King NW, Letvin NL, N L Letvin
Proceedings of the National Academy of Sciences of the United States of America · 1983 · vol. 80(16) , pp. 5085–9 · doi:10.1073/pnas.80.16.5085 · PMID:6576377 · PMC384193
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Researchers transmitted spontaneously occurring lymphomas from rhesus monkeys to healthy recipients using tumor cell suspensions, resulting in the development of undifferentiated or poorly differentiated lymphomas. The recipient animals exhibited clinical signs characteristic of acquired immune deficiency syndrome, including opportunistic infections like cytomegalovirus hepatitis and cryptosporidiosis, as well as abnormal circulating peripheral blood mononuclear cells. These findings indicate a strong association between the transmissible lymphomas and the onset of AIDS-like symptoms in macaques. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Spontaneously occurring rhesus monkey lymphomas were transmitted into healthy rhesus monkeys by using tumor cell suspensions. The naturally arising tumors included an immunoblastic sarcoma and an undifferentiated lymphoma. Recipient animals developed undifferentiated lymphomas, poorly differentiated lymphomas, or parenchymal lymphoproliferative abnormalities suggestive of early lesions of lymphoma. Some of these animals developed such opportunistic infections as cytomegalovirus hepatitis and cryptosporidiosis. They also showed evidence of an abnormal circulating peripheral blood mononuclear cell. These findings, all characteristic of the acquired immune deficiency syndrome (AIDS) of macaques, suggest a link between these transmissible lymphomas and AIDS in macaque monkeys.
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Abstract Spontaneously occurring rhesus monkey lymphomas were transmitted into healthy rhesus monkeys by using tumor cell suspensions. The naturally arising tumors included an immunoblastic sarcoma and an undifferentiated lymphoma. Recipient animals developed undifferentiated lymphomas, poorly differentiated lymphomas, or parenchymal lymphoproliferative abnormalities suggestive of early lesions of lymphoma. Some of these animals developed such opportunistic infections as cytomegalovirus hepatitis and cryptosporidiosis. They also showed evidence of an abnormal circulating peripheral blood mononuclear cell. These findings, all characteristic of the acquired immune deficiency syndrome (AIDS) of macaques, suggest a link between these transmissible lymphomas and AIDS in macaque monkeys. Full text PDFImages in this article Selected References These references are in PubMed. This may not be the complete list of references from this article. - Hunt R. D., Jones T. C. Nonhuman primates in viral oncology. Adv Vet Sci Comp Med. 1973;17:361–394. [PubMed] [Google Scholar] - Letvin N. L., Eaton K. A., Aldrich W. R., Sehgal P. K., Blake B. J., Schlossman S. F., King N. W., Hunt R. D. Acquired immunodeficiency syndrome in a colony of macaque monkeys. Proc Natl Acad Sci U S A. 1983 May;80(9):2718–2722. doi: 10.1073/pnas.80.9.2718. [DOI] [PMC free article] [PubMed] [Google Scholar] - Lingeman C. H., Reed R. E., Garner F. M. Spontaneous hematopoietic neoplasms of nonhuman primates. Review, case report, and comparative studies. Natl Cancer Inst Monogr. 1969 Aug;32:157–170. [PubMed] [Google Scholar] - Miller G., Shope T., Coope D., Waters L., Pagano J., Bornkamn G., Henle W. Lymphoma in cotton-top marmosets after inoculation with Epstein-Barr virus: tumor incidence, histologic spectrum antibody responses, demonstration of viral DNA, and characterization of viruses. J Exp Med. 1977 Apr 1;145(4):948–967. doi: 10.1084/jem.145.4.948. [DOI] [PMC free article] [PubMed] [Google Scholar] - Rangan S. R., Gallagher R. E. Tumors and viruses in nonhuman primates. Adv Virus Res. 1979;24:1–123. doi: 10.1016/s0065-3527(08)60392-9. [DOI] [PubMed] [Google Scholar] - Stowell R. E., Smith E. K., España C., Nelson V. G. Outbreak of malignant lymphoma in rhesus monkeys. Lab Invest. 1971 Nov;25(5):476–479. [PubMed] [Google Scholar]

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MeSH descriptors

Lymphoma Macaca Macaca mulatta Monkey Diseases Animals Lymphoma Lymphoma Lymphoma Male Monkey Diseases Monkey Diseases Neoplasm Transplantation

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