Effect of copper intrauterine device on the cyclooxygenase and inducible nitric oxide synthase expression in the luteal phase endometrium

Ebru Coskun, Ebru İnci Coşkun, Yiğit Çakıroğlu, Yigit Cakiroglu, Banu Aygün, Banu Kumbak Aygun, Bahar Müezzínoğlu, Bahar Muezzinoglu, Eray Caliskan, Eray Çalışkan
Contraception · 2011 · vol. 84(6) , pp. 637–641 · doi:10.1016/j.contraception.2011.03.027 · PMID:22078195 · W2036084826
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This study investigated the effect of copper intrauterine devices on cyclooxygenase and inducible nitric oxide synthase expression within the luteal phase endometrium.

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This study investigated the impact of copper intrauterine devices on the expression of cyclooxygenase and inducible nitric oxide synthase within the luteal phase endometrium. The researchers analyzed tissue samples to determine how the presence of the device alters these specific inflammatory markers during a particular stage of the menstrual cycle. Results indicated significant changes in enzyme expression levels associated with the IUD's mechanism of action. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

BACKGROUND: To evaluate the effect of copper intrauterine device (IUD) on the expression of cyclooxygenase (COX) and inducible nitric oxide synthase (iNOS) in the luteal phase endometrium. STUDY DESIGN: A prospective clinical study was conducted on 30 women who were willing to use a copper IUD contraception. Endometrial biopsies and blood samples were taken before and 3 months after the insertion of the IUD on Day 3 and Days 20-24 of the cycle. Main outcome measures were to evaluate the effect of copper IUD on uterine artery blood flow using pulsed color Doppler ultrasonography and the relationship of bleeding abnormalities and menstrual pain level with the uterine blood flow, COX-2 and iNOS expression. RESULTS: Only the left uterine artery pulsatility and resistance indices decreased statistically significantly (p=.005 and p=.039, respectively). Other Doppler parameters showed no change. Cyclooxygenase-2 expression of both endometrial luminal epithelium (p=.03) and gland epithelium (p=.03) increased significantly. Inducible NOS expression of the endometrial surface epithelium decreased significantly after IUD insertion (p=.01). CONCLUSIONS: Although COX-2 expression increased 3 months after copper IUD insertion, iNOS expression of the luminal epithelium decreased. Local hypoxia caused by copper and vasoconstrictor prostanoids may play a role in IUD-related menstrual abnormalities.
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Journal or Series Contraception WoS Q Value Scopus Q Value Volume 84 Issue 6 Citation Endorsement Review Supplemented By Referenced By Rights and licensing info:eu-repo/semantics/closedAccess

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Cyclooxygenase 2 Endometrium Intrauterine Devices, Copper Luteal Phase Nitric Oxide Synthase Type II Adolescent Adult Cyclooxygenase 2 Dysmenorrhea Dysmenorrhea Dysmenorrhea Endometrium Endometrium Epithelium Epithelium Epithelium Female Humans Intrauterine Devices, Copper Luteal Phase

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