Evaluation of predictive factors for multiple pregnancies during gonadotropin/IUI treatment.

Goldfarb JM; Peskin B; Austin C; Lisbona H

doi:10.1007/bf02765776

Evaluation of predictive factors for multiple pregnancies during gonadotropin/IUI treatment.

Goldfarb JM, Peskin B, Austin C, Lisbona H

Journal of assisted reproduction and genetics · 1997 · doi:10.1007/bf02765776 · PMID:9048238 · PMC3454823

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This review of 91 pregnancies found that while multiple follicles and lower postwash sperm counts were associated with multiple gestations during gonadotropin/IUI treatment, no predictive factors were sufficiently accurate to aid clinical management or counseling.

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This retrospective study analyzed 91 pregnancies resulting from human menopausal gonadotropin and intrauterine insemination treatment to identify factors predicting multiple gestations. The researchers found that while the multiple-pregnancy group had a greater number of follicles larger than 10 mm and fewer postwash sperm, no single factor or combination provided sufficient predictive power for clinical management or counseling. Consequently, the authors concluded that current monitored parameters are inadequate for reliably forecasting multiple births in this specific treatment context. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

PurposeOur purpose was to analyze factors for their predictability of multiple pregnancies in patients treated with a combination of human menopausal gonadotropins (hMG) and intrauterine insemination (IUI).MethodsThe records of all patients conceiving through treatment with hMG/IUI were reviewed for factors predictive of multiple pregnancy.ResultsNinety-one pregnancies reviewed included 78 singleton (86%), 8 twin (9%), and 5 higher-order pregnancies (5%). The total number of follicles > 10 mm was greater in the multiple-pregnancy group and there was a decreased number of postwash sperm in the multiple-pregnancy group. Otherwise there was no significant difference in the factors analyzed.ConclusionsNo factor or combination of factors predicts multiple pregnancies to a degree that it would be helpful in managing or counseling patients.

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Abstract

Purpose: Our purpose was to analyze factors for their predictability of multiple pregnancies in patients treated with a combination of human menopausal gonadotropins (hMG) and intrauterine insemination (IUI).

Methods

The records of all patients conceiving through treatment with hMG/IUI were reviewed for factors predictive of multiple pregnancy.

Results

Ninety-one pregnancies reviewed included 78 singleton (86%), 8 twin (9%), and 5 higher-order pregnancies (5%). The total number of follicles >10 mm was greater in the multiple-pregnancy group and there was a decreased number of postwash sperm in the multiple-pregnancy group. Otherwise there was no significant difference in the factors analyzed.

Conclusions

No factor or combination of factors predicts multiple pregnancies to a degree that it would be helpful in managing or counseling patients. Key words: human menopausal gonadotropins, intrauterine insemination, multiple pregnancy Full Text The Full Text of this article is available as a PDF (305.7 KB).

References

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