Does cabergoline administration affect endometrial VEGFR-2 expression in a rat model of ovarian hyperstimulation syndrome?

Nafiye Yilmaz, Nafiye Yılmaz, Pınar Çoban, Saynur Yılmaz, Saynur Yilmaz, Hasan Ali İnal, Hakan Tımur, Hakan Timur, Hacer Haltaş, Hacer Haltas
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2023 · vol. 39(1) , pp. 2217295 · doi:10.1080/09513590.2023.2217295 · PMID:37247633 · W4378714729
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Cabergoline administration in an OHSS rat model did not significantly alter endometrial VEGFR-2 expression, potentially impacting implantation and IVF success.

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Abstract

OBJECTIVE: To assess the effect of cabergoline on endometrial vascular endothelial growth factor receptor-2 (VEGFR-2) immunoexpression in an ovarian hyperstimulation syndrome (OHSS) rat model. MATERIAL AND METHODS: Twenty-one immature female Wistar rats were assigned into three groups: group 1, the control group; group 2, stimulated with gonadotropins to mimic OHSS; and group 3, in which an OHSS protocol was induced and thereafter treated with cabergoline (100 μg/kg/day). Body weight, ovarian volume, corpora lutea numbers, and endometrial VEGFR-2 expression were compared between the groups. RESULTS: Weight gain and ovarian volume were highest in the OHSS-placebo group, while cabergoline administration significantly reversed those effects (p = 0.001 and p = 0.001, respectively). VEGFR-2 stained cells were significantly lower in groups 2 and 3 compared to group 1 (p = 0.002). Although VEGFR-2 expression was lowest in group 3, the difference was not statistically significant. Corpora lutea numbers were also similar (p = 0.465). CONCLUSION: While successful implantation requires a vascularized receptive endometrium, impaired expression of VEGFR-2 and disrupted endometrial angiogenesis due to cabergoline administration may be associated with IVF failure in fresh OHSS cycles. The insignificant decrease in endometrial VEGFR-2 expression observed in this research needs to be investigated by further studies involving additional techniques such as immunoblotting and/or RT-PCR analyses.

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MeSH descriptors

Ovarian Hyperstimulation Syndrome Ovarian Hyperstimulation Syndrome Ovarian Hyperstimulation Syndrome Animals Cabergoline Cabergoline Dopamine Agonists Dopamine Agonists Ergolines Ergolines Female Rats Rats, Wistar Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-2 Vascular Endothelial Growth Factor Receptor-2

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