The effect of risperidone and quetiapine on reproductive hormone levels，bone mineral density and body mass index in female patients with schizophrenia

Jianjun Liu, Jushui Sun, Xinhua Shen, Weigang Guo, Shengli Zhi
In: Chin J Psychiatry · 2014 · vol. 47(05) , pp. 288–292 · doi:10.3760/cma.j.issn.1006-7884.2014.05.007 · W3031199650
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This study compared risperidone and quetiapine effects on reproductive hormones, bone density, and BMI in female schizophrenia patients, finding distinct hormonal impacts but similar bone mineral density outcomes.

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This randomized controlled trial evaluated the impact of risperidone versus quetiapine on reproductive hormones, bone mineral density, and body mass index in eighty first-episode female patients with schizophrenia over a twelve-month period. The study found that risperidone treatment resulted in significantly higher prolactin levels and lower estradiol concentrations compared to quetiapine, while also leading to reduced lumbar spine bone mineral density. Furthermore, changes in bone mineral density in the risperidone group were negatively correlated with prolactin increases and positively correlated with estradiol changes, whereas no such hormonal correlations were observed in the quetiapine group. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

Objective The main goal of this study was to assess the long-term effect of risperidone and quetiapine on reproductive hormone levels，bone mineral density and body mass index in first-episode female schizophrenia population. Methods Eighty patients in first-episode reproductive female schizophrenia were randomly assigned to treat with risperidone (n=40) or quetiapine (n=40) and followed 12 months.Reproductive hormone levels and body mass index were measured at baseline, 6 months, 12 months，and the femur, lumbar spine bone mineral density measured by using Dual energy X-ray absorptiometry. Results （1）At the end of 12th month, lumbar vertebra bone density in risperidone group and quetiapine group was （0.97±0.09） g/cm2 and（1.03±0.11） g/cm2, respectively （F=2.560，P=0.023）.(2)At the end of 6th，12th month, prolactin level in risperidone group was （92.4±37.5） nmol/L and（84.0±42.1） nmol/L，while （25.5±8.8） nmol/L and（27.4±6.1） nmol/L respectively in quetiapine group, and the difference between two groups was statistically significant（F=51.174，P<0.01；F=48.320，P<0.01）; Estradiol level was （146.2±103.2） pmol/L and（135.8±167.2） pmol/L in risperidone group，while （239.4±179.3） pmol/L and（246.4±184.6） pmol/L in quetiapine group（F=44.325，P<0.01；F=43.170，P<0.01）, and progesterone was（7.2±6.5） nmol/L and（7.2±5.2） nmol/L in risperidone group, while （8.9±6.9） nmol/L and（8.0±7.2） nmol/L in quetiapine group（F=7.454，P=0.026；F=9.573，P=0.036）. (3) Body mass inde was （25.73±2.77） kg/m2 and（26.14±3.30） kg/m2 in risperdone group,while（26.04±3.12） kg/m2 and（ 26.32±3.48） kg/m2 in quetiapine group at the end of 6th,12th month（F=0.419， P=0.685；F=0.216，P=0.823）.（4）In risperidone group, the altering rate of prolactin was negatively correlated with that of bone mineral density（r=-0.62，P=0.023）, while the altering rate of estradiol was positively correlated with that of bone mineral density（r=0.46，P=0.044）.In quetiapine group, the altering rate of prolactin, estradiol and progesterone was not correlated with that of bone mineral density.The altering rate of body mass index was positively correlated with that of bone mineral density in both groups. Conclusion The data indicates that there may be a different effect on prolactin, estradiol, progesterone and lumbar spine bone mineral density, and a similar effect on bone mineral density in the treatment with risperidone and quetiapine. Key words: Schizophrenia; Risperidone; Quetiapine; Reproductive hormone; Bone density; Body mass index
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利培酮和奎硫平治疗对女性精神分裂症患者生殖激素和骨密度及体质量的影响 The effect of risperidone and quetiapine on reproductive hormone levels, bone mineral density and body mass index in female patients with schizophrenia 摘要目的 探讨利培酮和奎硫平治疗对女性精神分裂症患者生殖激素和骨密度及体质量的影响及其相互关系.方法 共纳入首次发病女性精神分裂症患者80例,采用随机数字表法随机分为利培酮组(n=40)和奎硫平组(n=40),分别采用利培酮和奎硫平治疗12个月,于治疗基线和第6、12个月末测定体质量指数和血清促卵泡激素、黄体生成素、雌二醇、睾酮、孕酮、催乳素水平;测量腰椎2-4和左侧股骨颈3个位点的骨密度.结果 (1)治疗第12个月末,利培酮组和奎硫平组腰椎骨密度分别为(0.97 ±0.09)、(1.03±0.11) g/cm2,差异有统计学意义(F =2.560,P=0.023).(2)治疗第6、12个月末,利培酮组催乳素浓度分别为(92.4±37.5)、(84.0±42.1)nmol/L,奎硫平组分别为(25.5±8.8)、(27.4 ±6.1)nmol/L,相同时间点比较差异有统计学意义(F=51.174,P＜0.01;F =48.320,P＜0.01);治疗第6、12个月末,利培酮组雌二醇浓度分别为(146.2±103.2)、(135.8±167.2) pmol/L,奎硫平组分别为(239.4±179.3)、(246.4±184.6) pmol/L,相同时间点比较差异有统计学意义(F =44.325,P＜0.01;F=43.170,P＜0.01);治疗第6、12个月末利培酮组孕酮浓度分别为(7.2±6.5)、(7.2±5.2)nmol/L,奎硫平组分别为(8.9±6.9)、(8.0±7.2)nmol/L,相同时间点比较差异有统计学意义(F =7.454,P=0.026;F =9.573,P=0.036).(3)治疗第6、12个月末利培酮组体质量指数分别为(25.73±2.77)、(26.14 ±3.30)kg/m2,奎硫平组分别为(26.04±3.12)、(26.32±3.48) kg/m2,相同时间点比较差异无统计学意义(F =0.419,P=0.685;F =0.216,P=0.823).(4)治疗第12个月末,利培酮组腰椎骨密度变化率与催乳素变化率呈负相关(r=-0.62,P=0.023),与雌二醇变化率呈正相关(r =0.46,P=0.044),与体质量指数变化率呈正相关(r=0.58,P=0.035),与孕酮变化率无相关性(r =0.26,P=0.091);奎硫平组腰椎骨密度变化率与体质量指数变化率呈正相关(r=0.52,P=0.041),与催乳素、雌二醇、孕酮变化率无相关性.结论 利培酮和奎硫平治疗对血清催乳素、雌激素、孕酮、腰椎骨密度影响不同,对体质量影响相似,腰椎骨密度与催乳素、雌二醇、体质量相关. 更多相关知识 abstractsObjective The main goal of this study was to assess the long-term effect of risperidone and quetiapine on reproductive hormone levels,bone mineral density and body mass index in first-episode female schizophrenia population.Methods Eighty patients in first-episode reproductive female schizophrenia were randomly assigned to treat with risperidone (n =40) or quetiapine (n =40) and followed 12 months.Reproductive hormone levels and body mass index were measured at baseline,6 months,12 months,and the femur,lumbar spine bone mineral density measured by using Dual energy X-ray absorptiometry.Results (1)At the end of 12th month,lumbar vertebra bone density in risperidone group and quetiapine group was (0.97 ± 0.09) g/cm2 and (1.03 ± 0.11) g/cm2,respectively (F =2.560,P =0.023).(2) At the end of 6th,12th month,prolactin level in risperidone group was (92.4 ± 37.5) nmol/L and (84.0 ± 42.1) nmol/L,while (25.5 ± 8.8) nmol/L and(27.4 ± 6.1) nmol/L respectively in quetiapine group,and the difference between two groups was statistically significant (F =51.174,P ＜ 0.01 ; F =48.320,P ＜0.01) ; Estradiol level was (146.2 ± 103.2) pmol/L and(135.8 ± 167.2) pmol/L in risperidone group,while (239.4 ± 179.3) pmol/L and(246.4 ± 184.6) pmol/L in quetiapine group(F =44.325,P ＜0.01 ; F =43.170,P ＜ 0.01),and progesterone was (7.2 ± 6.5) nmol/L and (7.2 ± 5.2) nmol/L in risperidone group,while (8.9 ± 6.9) nmol/L and(8.0 ± 7.2) nmol/L in quetiapine group(F =7.454,P =0.026 ; F =9.573,P=0.036).(3) Body mass inde was (25.73 ±2.77) kg/m2 and(26.14±3.30) kg/m2 in risperdone group,while(26.04 ±3.12) kg/m2 and(26.32 ±3.48) kg/m2 in quetiapine group at the end of 6th,12th month (F =0.419,P =0.685 ; F =0.216,P =0.823).(4) In risperidone group,the altering rate of prolactin was negatively correlated with that of bone mineral density (r =-0.62,P =0.023),while the altering rate of estradiol was positively correlated with that of bone mineral density(r =0.46,P =0.044).In quetiapine group,the altering rate of prolactin,estradiol and progesterone was not correlated with that of bone mineral density.The altering rate of body mass index was positively correlated with that of bone mineral density in both groups.Conclusion The data indicates that there may be a different effect on prolactin,estradiol,progesterone and lumbar spine bone mineral density,and a similar effect on bone mineral density in the treatment with risperidone and quetiapine. More相关知识 - 浏览0 - 被引26 - 下载0 相似文献 - 中文期刊 - 外文期刊 - 学位论文 - 会议论文

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