[Suppressive effect of the blast cells of AKR strain mice on antibody formation in vivo and lymphocyte proliferation in vitro]

N V Kashlakova; L.V. Adamyan; М. Л. Алексеева; I A Lisukov; Н. Н. Жукова; I G Tsyrlova; N V Vasil'ev; L S Minina; V A Kozlov; Е. А. Новиков

doi:10.1007/bf00835688

[Suppressive effect of the blast cells of AKR strain mice on antibody formation in vivo and lymphocyte proliferation in vitro]

N V Kashlakova, L.V. Adamyan, М. Л. Алексеева, I A Lisukov, Н. Н. Жукова, I G Tsyrlova, N V Vasil'ev, L S Minina, V A Kozlov, Е. А. Новиков

Biulleten' eksperimental'noi biologii i meditsiny · 1988 · vol. 105(2) , pp. 184–185 · doi:10.1007/bf00835688 · PMID:3349148 · W2410772565

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This abstract describes the suppressive effects of blast cells on mouse splenocytes and immune responses, suggesting a link to leukemia pathogenesis, rather than addressing endometriosis or adenomyosis.

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Abstract

Blast cells obtained from the "erythropoietic spleen" of FG-stimulated young mice and cells accumulating in the spleens of preleukemic AKR mice have a marked suppressive effect on spontaneous and mitogen-induced proliferation of young mouse splenocytes in vitro and suppress the development of humoral immune response in immunized recipients during syngeneic transfer in vivo. Some disturbances in erythron system in preleukemic AKR mice manifested in the accumulation of immature erythroid precursors which are suppressors of immunocompetent lymphocytes are suggested to be a pathogenetic link in the development of leukemia.

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MeSH descriptors

Antibody Formation Antibody Formation Immune Tolerance Immune Tolerance Lymphocytes Mice, Inbred AKR Animals Cell Division Cell Division Cells, Cultured Erythropoiesis Immunization Lymphocytes Lymphocytes Lymphocytes Mice Mice, Inbred AKR Phenylhydrazines Phenylhydrazines Preleukemia

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Too few in-corpus citations on either side for a chart; here are the lists.

Cites (3)

References (6)

In vitro effect of danazol on steroidogenesis in developing human follicles. An interim report via openalex
Short-term effects of danazol on endometrial histology via openalex
Steroidal regulation of endometriosis tissue: lack of induction of 17 beta-hydroxysteroid dehydrogenase activity by progesterone, medroxyprogesterone acetate, or danazol via openalex
doi:10.1042/bj1260561 via openalex
doi:10.1016/0022-4731(76)90034-0 via openalex
doi:10.1016/s0015-0282(16)43869-0 via openalex

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[1] Steroidal regulation of endometriosis tissue: lack of induction of 17 beta-hydroxysteroid dehydrogenase activity by progesterone, medroxyprogesterone acetate, or danazol 1985

[2] Short-term effects of danazol on endometrial histology 1984

[3] In vitro effect of danazol on steroidogenesis in developing human follicles. An interim report 1984