Vascular endothelial growth factor, interleukin-6 and interleukin-2 in serum and follicular fluid of patients with ovarian hyperstimulation syndrome

P. G. Artini, Paolo Giovanni Artini, M Monti, Massimiliano Monti, A Fasciani, Alessandro Fasciani, Cesare Battaglia, C Battaglia, G D'Ambrogio, G D’Ambrogio, A. R. Genazzani, Andrea Riccardo Genazzani
European Journal of Obstetrics & Gynecology and Reproductive Biology · 2002 · vol. 101(2) , pp. 169–174 · doi:10.1016/s0301-2115(01)00568-1 · PMID:11858893 · W2108565435
Observational OA: closed CC0 ⤵ 1 in-corpus citation
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study investigated the concentrations of vascular endothelial growth factor, interleukin-6, and interleukin-2 in serum and follicular fluid of patients experiencing ovarian hyperstimulation syndrome.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

BACKGROUND: The pathogenesis of ovarian hyperstimulation syndrome (OHSS) is not completely understood. OBJECTIVE: To investigate the presence of VEGF, IL-6 and IL-2, in serum and follicular fluid, in patients developing severe OHSS. STUDY DESIGN: We enrolled 101 women undergoing in vitro fertilization. Eight patients developing severe OHSS were compared with 43 high risk patients and 50 controls. We analyzed VEGF and IL-6 in serum collected before hCG administration, and in both serum and follicular fluid on the day of oocyte retrieval. RESULTS: OHSS patients presented follicular fluid IL-6 levels higher than both the patients at risk and controls (P<0.05). On the day of the oocyte retrieval the patients developing OHSS showed serum and follicular VEGF values higher than the ones of the patients at risk (P<0.05). Serum and follicular fluid IL-2 levels showed no differences between the examined groups. IL-2, IL-6 and VEGF values were not correlated with each other. CONCLUSIONS: Angiogenesis and inflammation processes are both present in severe OHSS.

My notes (saved in your browser only)

MeSH descriptors

Endothelial Growth Factors Follicular Fluid Interleukin-2 Interleukin-6 Lymphokines Ovarian Hyperstimulation Syndrome Adult Case-Control Studies Chorionic Gonadotropin Chorionic Gonadotropin Endothelial Growth Factors Endothelial Growth Factors Female Follicular Fluid Humans Interleukin-2 Interleukin-2 Interleukin-6 Interleukin-6 Lymphokines

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (3)

Cited by (1)

References (29)

Cited by (1)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-10-08T21:00:24.492322+00:00
unpaywall
last seen: 2026-10-23T06:24:35.503409+00:00
License: CC0 · commercial use OK