Long-term Effects of Mifepristone in the Treatment of Non-radical Postoperative Endometriosis and its Impact on Sex hormones

Yanhui Chen
In: Zhongguo linchuang shiyong yixue · 2010 · vol. 4(01) , pp. 29–31 · doi:10.3760/cma.j.issn.1673-8799.2010.01.15 · W3031922571
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Low-dose mifepristone significantly improved long-term outcomes for non-radical postoperative endometriosis patients while inducing reversible decreases in serum estrogen and progesterone levels without altering follicle-stimulating hormone or prolactin concentrations.

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This study evaluated the long-term efficacy of low-dose mifepristone in 200 patients with non-radical postoperative endometriosis who underwent laparoscopic surgery. Participants received a six-month treatment regimen, resulting in a 95.5% clinical effectiveness rate and significant reductions in serum progesterone levels, while estradiol decreased to mid-follicular phases. The research noted that hormonal changes and menstrual cycles were reversible after discontinuation, with only minor relapse rates observed within one year. This paper is centrally about endometriosis — specifically examining the pharmacological management and hormonal impacts following surgical intervention for the condition.

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Abstract

Objective To explore long-term effects of low-dose mifepristone in non-radical postoperativeendometriosis patients and its impact on sex hormones. Methods 200 cases of endometriosis who underwent non-radical laparoscopic surgery were included in the study. Continuous treatment of oral mifepristone was given to those patients for 6 months(25 mg/d for 3 months and then 12.5 mg/d for another 3 months). B-ultrasound and pelvic examination were conducted before treatment, 3 months and 6 months after medication, 3 months, 6 months and 12 months after discontinuation of treatment respectively. Peripheral blood was collected to evaluate the changes of sex hormones. Results The overall effectiveness after 6 months treatment was 95.5% (191/200). Normal menstruation was resumed 1 month after the discontinuation of treatment. 6 cases relapsed within 6 months, and 27 cases relapsed within 1 year after the discontinuation of treatment respectively ( 6/191,3.1%;27/191,14.1%). After oral administration of mifepristone, serum E2 decreased to the mid-follicular levels. Serum FSH and PRL levels remained unchanged( P ＞ 0.05 ). Serum progesterone levels decreased significantly after treatment ( P ＜ 0.05 ). LH increased insignificantly ( P ＞ 0.05 ). Conclusion Continuous use of low-dose mifepristone can improve long-term effects of non-radical postoperative endometriosis. Reversible changes are expected in menses and serum sex hormone levels. The treatment is safe and its adverse effects are scares. Key words: Endometriosis;  Mifepristone;  Sex hormones
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子宫内膜异位症非根治性手术后应用米非司酮的远期疗效及其对性激素的影响 Long-term Effects of Mifepristone in the Treatment of Non-radical Postoperative Endometriosis and its Impact on Sex hormones 摘要目的 探索对非根治性子宫内膜异位症术后患者,长期服用小剂量米非司酮对临床症状改善及性激素水平的影响.方法 选择200例非根治性腹腔镜手术后确诊为子宫内膜异位症的患者,术后口服米非司酮治疗6个月(25 mg/d×3个月;之后12.5 mg/d×3个月).分别于服药前,服药后3个月及6个月,停药后3、6及12个月进行B超及妇科检查了解盆腔情况,同时采集外周血测定性激素水平.结果 服药6个月后临床总有效率为95.5%(191/200),停药后1个月左右月经恢复正常.治疗有效者中有6例在停药后的6个月内复发(6/191,3.1%),27例在停药后1年内症状再次加重或复发(27/191,14.1%).口服米非司酮后,血清E2水平降至卵泡中期水平,FSH和PRL水平在治疗前、后均无明显变化(P＞0.05).血P水平比用药前显著降低(P＜0.05),LH稍升高(P＞0.05).结论 非根治性子宫内膜异位症术后长期服用小剂量米非司酮,可有效提高其远期疗效,对月经及性激素的影响是可逆的.其不良反应少,安全性较高. 更多相关知识 abstractsObjective To explore long-term effects of low-dose mifepristone in non-radical postoperativeendometriosis patients and its impact on sex hormones. Methods 200 cases of endometriosis who underwent non-radical laparoscopic surgery were included in the study. Continuous treatment of oral mifepristone was given to those patients for 6 months(25 mg/d for 3 months and then 12.5 mg/d for another 3 months). B-ultrasound and pelvic examination were conducted before treatment, 3 months and 6 months after medication, 3 months, 6 months and 12 months after discontinuation of treatment respectively. Peripheral blood was collected to evaluate the changes of sex hormones. Results The overall effectiveness after 6 months treatment was 95.5% (191/200). Normal menstruation was resumed 1 month after the discontinuation of treatment. 6 cases relapsed within 6 months, and 27 cases relapsed within 1 year after the discontinuation of treatment respectively ( 6/191,3.1%;27/191,14.1%). After oral administration of mifepristone, serum E2 decreased to the mid-follicular levels. Serum FSH and PRL levels remained unchanged( P ＞ 0.05 ). Serum progesterone levels decreased significantly after treatment ( P ＜ 0.05 ). LH increased insignificantly ( P ＞ 0.05 ). Conclusion Continuous use of low-dose mifepristone can improve long-term effects of non-radical postoperative endometriosis. Reversible changes are expected in menses and serum sex hormone levels. The treatment is safe and its adverse effects are scares. More相关知识 - 浏览0 - 被引2 - 下载0 相似文献 - 中文期刊 - 外文期刊 - 学位论文 - 会议论文

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