Increased levels of prostaglandin E2 and bcl-2 in peritoneal fluid and serum of patients with endometriosis

李志刚, 郎景和, 冷金花, 刘东远
In: Chin J Obstet Gynecol · 2005 · vol. 40(09) , pp. 598–600 · doi:10.3760/j.issn:0529-567x.2005.09.006 · W3031260811
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Patients with endometriosis exhibit significantly higher peritoneal fluid and serum levels of prostaglandin E2 and bcl-2 compared to controls, with concentrations increasing in association with advanced disease stages.

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This study investigated the levels of prostaglandin E2 (PGE2) and bcl-2 protein in both peritoneal fluid and serum of patients with endometriosis compared to a control group. Using enzyme-linked immunosorbent assay, researchers analyzed samples from 36 endometriosis patients and 30 controls, finding significantly higher concentrations of both biomarkers in the endometriosis group. The results indicated that PGE2 and bcl-2 levels were elevated in more advanced stages of the disease and were consistently higher in peritoneal fluid than in serum. This paper is centrally about endometriosis — specifically examining the role of PGE2 and bcl-2 in its pathogenesis and progression.

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Abstract

目的 探讨子宫内膜异位症(内异症)患者腹腔液及血清中,前列腺素E2(PGE2)和bcl-2蛋白的含量变化及其与内异症发病的关系.方法采用酶联免疫吸附法(ELISA)检测36例内异症患者(内异症组,其中Ⅰ、Ⅱ期患者16例,Ⅲ、Ⅳ期患者20例)和30例因卵巢囊肿或浆膜下子宫肌瘤手术患者(对照组)腹腔液及血清PGE2与bcl-2含量.结果内异症组患者腹腔液中PGE2、bcl-2蛋白的含量分别为(1987±532)ng/L、(177±53)U/L,对照组为(386±215) ng/L、(86±21)U/L,两组比较,差异均有统计学意义(P<0.01).Ⅲ、Ⅳ期内异症患者腹腔液中PGE2的含量[(2221±1352)ng/L]较Ⅰ、Ⅱ期患者[(1694±381)ng/L]明显升高,差异也有统计学意义(P<0.01); Ⅲ、Ⅳ期内异症患者腹腔液中bcl-2的含量[(190±63) U/L]较Ⅰ、Ⅱ期患者[(162±49) U/L]升高,差异有统计学意义(P＜0.05).内异症组血清中的PGE2与bcl-2含量[(3787±514)ng/L、(96±44)U/L]均高于对照组[(129±97)ng/L、(53±40)U/L],差异均有统计学意义(P<0.01).Ⅲ、Ⅳ期内异症患者血清中的PGE2含量[(964±290)ng/L]也高于Ⅰ、Ⅱ期患者[(590±362)ng/L],差异也有统计学意义(P<0.01);内异症患者腹腔液中PGE2及bcl-2的含量均高于血清.结论内异症患者腹腔中高含量的PGE2与bcl-2,可能对内异症发病有影响;内异症患者腹腔液与血清中PGE2和bcl-2含量与病变的范围有一定关系。
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子宫内膜异位症患者腹腔液及血清中前列腺素E2与bcl-2蛋白的含量变化及意义 Increased levels of prostaglandin E2 and bcl-2 in peritoneal fluid and serum of patients with endometriosis 摘要目的探讨子宫内膜异位症(内异症)患者腹腔液及血清中,前列腺素E2(PGE2)和bcl-2蛋白的含量变化及其与内异症发病的关系.方法采用酶联免疫吸附法(ELISA)检测36例内异症患者(内异症组,其中Ⅰ、Ⅱ期患者16例,Ⅲ、Ⅳ期患者20例)和30例因卵巢囊肿或浆膜下子宫肌瘤手术患者(对照组)腹腔液及血清PGE2与bcl-2含量.结果内异症组患者腹腔液中PGE2、bcl-2蛋白的含量分别为(1987±532)ng/L、(177±53)U/L,对照组为(386±215) ng/L、(86±21)U/L,两组比较,差异均有统计学意义(P<0.01).Ⅲ、Ⅳ期内异症患者腹腔液中PGE2的含量[(2221±1352)ng/L]较Ⅰ、Ⅱ期患者[(1694±381)ng/L]明显升高,差异也有统计学意义(P<0.01); Ⅲ、Ⅳ期内异症患者腹腔液中bcl-2的含量[(190±63) U/L]较Ⅰ、Ⅱ期患者[(162±49) U/L]升高,差异有统计学意义(P＜0.05).内异症组血清中的PGE2与bcl-2含量[(3787±514)ng/L、(96±44)U/L]均高于对照组[(129±97)ng/L、(53±40)U/L],差异均有统计学意义(P<0.01).Ⅲ、Ⅳ期内异症患者血清中的PGE2含量[(964±290)ng/L]也高于Ⅰ、Ⅱ期患者[(590±362)ng/L],差异也有统计学意义(P<0.01);内异症患者腹腔液中PGE2及bcl-2的含量均高于血清.结论内异症患者腹腔中高含量的PGE2与bcl-2,可能对内异症发病有影响;内异症患者腹腔液与血清中PGE2和bcl-2含量与病变的范围有一定关系. 更多相关知识 - 浏览314 - 被引15 - 下载12 相似文献 - 中文期刊 - 外文期刊 - 学位论文 - 会议论文

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