Science (New York, N.Y.)

For decades, we have known that women, especially younger women, are disproportionately affected by pain disorders, including irritable bowel syndrome, endometriosis, menstrual migraines, fibromyalgia, osteoarthritis, and neuropathic pain, …

Studies of rodents with a menstrual on/off switch could help people with endometriosis and other disorders.

Katie Burns is helping uncover the role of the immune system in endometriosis-while managing her own disease.

Among mammals, post-reproductive life spans are currently documented only in humans and a few species of toothed whales. Here we show that a post-reproductive life span exists among wild chimpanzees in the Ngogo community of Kibale National…

Glycosylation alterations are indicative of tissue inflammation and neoplasia, but whether these alterations contribute to disease pathogenesis is largely unknown. To study the role of glycan changes in pancreatic disease, we inducibly expr…

A signaling pathway connects ovarian hormones to preparation of the mammalian uterus for pregnancy.

Ovarian clear cell carcinoma (OCCC) is an aggressive human cancer that is generally resistant to therapy. To explore the genetic origin of OCCC, we determined the exomic sequences of eight tumors after immunoaffinity purification of cancer …

Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year …

Endometriosis is a disease defined by the presence of endometrial tissue outside of the uterus. Severe pelvic pain is often associated with endometriosis, and this pain can be diminished with therapies that suppress estrogen production. Man…

In four experimental and five control monkeys, we recorded 178 menstrual cycles. Unilateral temporal lobectomy in two animals had no effect upon lengths of menstrual cycles. Bilateral lesions in two animals affected menstrual function, prod…